NGFR Protein (Fc Tag)
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- 抗原 See all NGFR 蛋白
- NGFR (Nerve Growth Factor Receptor (NGFR))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This NGFR protein is labelled with Fc Tag.
- 原理
- Recombinant Mouse NGFR/CD271 Protein (Fc Tag)(Active)
- 序列
- Met 1-Asn 243
- 产品特性
- A DNA sequence encoding the extracellular domain of mouse NGFR (Q9Z0W1) (Met 1-Asn 243) was fused with the Fc region of human IgG1 at the C-terminus.
- 纯度
- > 90 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to inhibit NGF-dependent proliferation of TF-1 human erythroleukemic cells.The ED50 for this effect is typically 0.5-3 μg/mL in the presence of 2 ng/mL Recombinant mouse NGF.
- Top Product
- Discover our top product NGFR 蛋白
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Nerve Growth Factor Receptor (NGFR) (AA 1-427) protein (GST tag)
NGFR 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Nerve Growth Factor Receptor (NGFR) (AA 32-140) protein (GST tag)NGFR 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Nerve Growth Factor Receptor (NGFR) protein (His tag)NGFR 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE
Nerve Growth Factor Receptor (NGFR) (AA 273-427) protein (His tag)Crystallography grade NGFR 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
Nerve Growth Factor Receptor (NGFR) (AA 266-417) protein (His tag)Crystallography grade NGFR 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
Nerve Growth Factor Receptor (NGFR) (AA 22-246) protein (His tag)Crystallography grade NGFR 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
Nerve Growth Factor Receptor (NGFR) (AA 29-427) protein (rho-1D4 tag)Crystallography grade NGFR 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
Nerve Growth Factor Receptor (NGFR) (AA 22-417) protein (rho-1D4 tag)Crystallography grade NGFR 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
Nerve Growth Factor Receptor (NGFR) protein (Myc-DYKDDDDK Tag)NGFR 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- NGFR (Nerve Growth Factor Receptor (NGFR))
- 别名
- NGFR/CD271 (NGFR 产品)
- 别名
- ngfr Protein, wu:fb38c02 Protein, wu:fc10h01 Protein, CD271 Protein, Gp80-LNGFR Protein, TNFRSF16 Protein, p75(NTR) Protein, p75NTR Protein, LNGFR Protein, RNNGFRR Protein, Tnfrsf16 Protein, p75 Protein, NRH1b Protein, fullback Protein, nrh1 Protein, p75ntr Protein, tnfrsf16 Protein, p75NGFR Protein, nerve growth factor receptor Protein, neurotrophin receptor associated death domain Protein, nerve growth factor receptor S homeolog Protein, nerve growth factor receptor (TNFR superfamily, member 16) Protein, NGFR Protein, nradd Protein, Ngfr Protein, ngfr.S Protein
- 背景
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Background: Nerve growth factor receptors (NGFRs) belong to a large growth factor receptor family. NGFR includes two types of receptors: high-affinity nerve growth factor receptor and low-affinity nerve growth factor receptor. High-affinity nerve growth factor receptor is also referred as Trk familywhose members are bound by some neurotrophins with high affinity. Nerve growth factor binds with TrkA after being released from target cells, the NGF / TrkA complex is subsequently trafficked back to the cell body. The Low-affinity nerve growth factor receptor also named p75 which binds with all kinds of neurotrophins with low affinity. All the four kinds of neurotrophins, including Nerve growth factor, Brain derived neurotrophic factor, Neurotrophin-3, and Neurotrophin-4 bind to the p75. Studies have proved that NGFR acts as a molecular signal swith that determines cell death or survival by three steps. First, pro-nerve growth factor (prNGF) triggers cell apoptosis by its high affinity binding to p75NTR, while NGF induces neuronal survival with low-affinity binding. Second, p75NTR mediates cell death by combining with co-receptor sortilin, whereas it promotes neuronal survival through combination with proNGF. Third, release of the intracellular domain chopper or cleavage short p75 NTR can independently initiate neuronal apoptosis.
Synonym: LNGFR,p75,p75NGFR,p75NTR,RP23-67E18.6,Tnfrsf16
- 分子量
- 50.6 kDa
- UniProt
- Q9Z0W1
- 途径
- NF-kappaB Signaling, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding
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