MAPK13 Protein (GST tag)
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- 抗原 See all MAPK13 蛋白
- MAPK13 (Mitogen-Activated Protein Kinase 13 (MAPK13))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- Baculovirus infected Insect Cells
- 标记
- This MAPK13 protein is labelled with GST tag.
- 原理
- Recombinant Human p38 delta/MAPK13 Protein (GST Tag)
- 序列
- Met 1-Leu 365
- 产品特性
- A DNA sequence encoding the full length of human MAPK13 (O15264) (Met 1-Leu 365) was fused with the GST tag at the N-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product MAPK13 蛋白
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Mitogen-Activated Protein Kinase 13 (MAPK13) (AA 1-365) (Active) protein (GST tag)
MAPK13 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant SDS, Func Active
Mitogen-Activated Protein Kinase 13 (MAPK13) (AA 1-365) (Active) proteinMAPK13 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant SDS, Func Active
Mitogen-Activated Protein Kinase 13 (MAPK13) (AA 1-365) protein (GST tag)MAPK13 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA, KAA
Mitogen-Activated Protein Kinase 13 (MAPK13) (AA 251-365) protein (GST tag)MAPK13 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Mitogen-Activated Protein Kinase 13 (MAPK13) protein (Myc-DYKDDDDK Tag)MAPK13 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 2 mM GSH, 10 % glycerol, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- MAPK13 (Mitogen-Activated Protein Kinase 13 (MAPK13))
- 别名
- p38 delta/MAPK13 (MAPK13 产品)
- 别名
- F24B9.3 Protein, F24B9_3 Protein, MAPK 13 Protein, MAPK-13 Protein, PRKM13 Protein, SAPK4 Protein, p38delta Protein, Serk4 Protein, Prkm13 Protein, sapk4 Protein, prkm13 Protein, Protein kinase superfamily protein Protein, mitogen-activated protein kinase 13 Protein, mitogen activated protein kinase 13 Protein, ATMPK13 Protein, MAPK13 Protein, Mapk13 Protein, mapk13 Protein
- 背景
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Background: The p38 family of mitogen-activated protein kinases (MAPK) includes p38 alpha (SAPK2a, CSBP), p38 beta (SAPK2b), p38 delta (SAPK4), and p38 gamma (SAPK3/ERK6). p38 alpha and p38 beta are widely expressed p38 isoforms that are involved in regulation of cell proliferation, differentiation, development, and response to stress. p38 delta, also known as MAPK13, is a regulator of differentiation-dependent gene expression in keratinocytes, and been as a regulator of surface epithelia differentiation and apoptosis. p38 delta protein is upregulated in Cholangiocarcinoma (CC) relative to hepatocellularcarcinoma (HCC) and to normal biliary tract tissues. p38 delta is important for motility and invasion of CC cells, suggesting that p38 delta may play an important role in CC metastasis. p38 delta is expressed in the epidermis, suggesting a role for p38 delta in regulating differentiation. p38 delta is the major p38 isoform driving suprabasal involucrin gene expression and that p38 delta directly regulates ERK1/2 activity via formation of a p38 delta-ERK1/2 complex. Recent emerging evidence suggests that the p38 stress MAPK pathway may function as a tumor suppressor through regulating Ras-dependent and -independent proliferation, transformation, invasion and cell death by isoform-specific mechanisms. p38 delta has important role in promoting cell proliferation and tumor development in epidermis and may have therapeutic implication for skin cancer.
Synonym: MAPK-13,MAPK13,p38delta,PRKM13,SAPK4
- 分子量
- 68.4 kDa
- UniProt
- O15264
- 途径
- MAPK Pathway, Neurotrophin Signaling Pathway, Hepatitis C, BCR Signaling, S100 Proteins
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