MST1R Protein (His tag)
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- 抗原 See all MST1R 蛋白
- MST1R (Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This MST1R protein is labelled with His tag.
- 原理
- Recombinant Human CD136/MST1R Protein (His Tag)
- 序列
- Met 1-Leu 571
- 产品特性
- A DNA sequence encoding the amino acid sequence (Met 1-Leu 571) of human CD136 (Q04912) extracellular domain was fused with a polyhistidine tag at the C-terminus.
- 纯度
- > 98 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product MST1R 蛋白
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Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R) (AA 26-125) protein (GST tag)
MST1R 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- MST1R (Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R))
- 别名
- CD136/MST1R (MST1R 产品)
- 别名
- CD136 Protein, CDw136 Protein, PTK8 Protein, RON Protein, Fv-2 Protein, Fv2 Protein, Ron Protein, STK Protein, Cdw136 Protein, Ptk8 Protein, Stk Protein, macrophage stimulating 1 receptor Protein, macrophage stimulating 1 receptor (c-met-related tyrosine kinase) Protein, MST1R Protein, Mst1r Protein
- 背景
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Background: The tyrosine kinase receptor, macrophage-stimulating 1 receptor (MST1R), a c-met-related tyrosine kinase, also known as the Ron receptor or CD136, controls cell survival and motility programs related to invasive growth. As tyrosine kinase receptor comprised of an extra-cellular domain, MST1R protein contains the ligand binding pocket and an intracellular region where the kinase domain is located. MST1R signaling may be involved in the regulation of macrophage and T-lymphocyte activation in vivo during injury. This assessment of gene expression indicates the importance of genetic factors in contributing to lung injury, and points to strategies for intervention in the progression of inflammatory diseases. It had been shown that MST1R/CD136 plays a critical role in Ni-induced lung injury in mice. The overexpression of MSP, MT-SP1, and MST1R was a strong independent indicator of both metastasis and death in human breast cancer patients and significantly increased the accuracy of an existing gene expression signature for poor prognosis. Stimulation of MST1R leads to its transphosphorylation and the ultimate activation of numerous intracellular signaling pathways, such as the classical mitogen-activated protein kinase pathway, the phosphotidylinositol (PI)3-kinase pathway, and the JNK pathway.
Synonym: CD136,CDw136,PTK8,RON
- 分子量
- 60 kDa
- UniProt
- Q04912
- 途径
- RTK signaling
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