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LILRB3 Protein (His tag)

LILRB3 宿主: 人 宿主: HEK-293 Cells Recombinant > 97 % as determined by reducing SDS-PAGE.
产品编号 ABIN7317447
发货至: 中国
  • 抗原 See all LILRB3 蛋白
    LILRB3 (Leukocyte Immunoglobulin-Like Receptor B3 (LILRB3))
    蛋白类型
    Recombinant
    宿主
    • 14
    • 6
    资源
    • 10
    • 5
    • 4
    • 1
    HEK-293 Cells
    标记
    This LILRB3 protein is labelled with His tag.
    原理
    Recombinant Human LILRB3/LIR3/ILT5/CD85a Protein (His Tag)
    序列
    Met 1-Glu 443
    产品特性
    A DNA sequence encoding the human LILRB3 (NP_006855.2) extracellular domain (Met 1-Glu 443) was expressed, with a polyhistidine tag at the C-terminus.
    纯度
    > 97 % as determined by reducing SDS-PAGE.
    内毒素水平
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product LILRB3 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Please refer to the printed manual for detailed information.
    缓冲液
    Lyophilized from sterile PBS, pH 7.4
    储存条件
    4 °C,-20 °C,-80 °C
    储存方法
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原
    LILRB3 (Leukocyte Immunoglobulin-Like Receptor B3 (LILRB3))
    别名
    LILRB3/LIR3/ILT5/CD85a (LILRB3 产品)
    别名
    CD85A Protein, HL9 Protein, ILT-5 Protein, ILT5 Protein, LILRA6 Protein, LIR-3 Protein, LIR3 Protein, PIRB Protein, Gp91 Protein, Lilrb3 Protein, PIR-B Protein, Pirb Protein, NILR-1 Protein, LILRB3 Protein, leukocyte immunoglobulin like receptor B3 Protein, paired Ig-like receptor B Protein, leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 Protein, LILRB3 Protein, Pirb Protein
    背景

    Background: Leukocyte immunoglobulin-like receptor subfamily B member 3, also known as Leukocyte immunoglobulin-like receptor 3, Immunoglobulin-like transcript 5, Monocyte inhibitory receptor HL9, CD85 antigen-like family member A, CD85a and LILRB3, is a single-pass type I  membrane protein which belongs to the leukocyte receptor cluster (LRC) present on 19q13.4. LILRB3 / CD85a contains four Ig-like C2-type (immunoglobulin-like) domains. LILRB3 / CD85a contains three copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. LILRB3 / CD85a is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found.

    Synonym: CD85A;HL9;ILT-5;ILT5;LILRA6;LIR-3;LIR3;MGC138403;PIRB;XXbac-BCX105G6.7

    分子量
    47.6 kDa
    NCBI登录号
    NP_006855
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