LIFR Protein (His tag)
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- 抗原 See all LIFR 蛋白
- LIFR (Leukemia Inhibitory Factor Receptor alpha (LIFR))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This LIFR protein is labelled with His tag.
- 原理
- Recombinant Mouse LIFR/CD118 Protein (His Tag)(Active)
- 序列
- Met 1-Ser 828
- 产品特性
- A DNA sequence encoding the extracellular domain of mouse LIFR (NP_038612.1) (Met 1-Ser 828) was expressed, with a polyhistidine tag at the C-terminus.
- 纯度
- > 95 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- 1. Measured by its ability to bind mouse LIF-Fc in a functional ELISA.2. Measured by its ability to inhibit the recombinant human LIF mediated inhibition in the M1 mouse myeloid leukemia cells. The ED50 for this effect is typically 5-20 ng/mL in the presence of 2 ng/mL recombinant human LIF.
- Top Product
- Discover our top product LIFR 蛋白
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Leukemia Inhibitory Factor Receptor alpha (LIFR) (AA 45-833) protein (His tag)
LIFR 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Leukemia Inhibitory Factor Receptor alpha (LIFR) protein (Fc Tag)LIFR 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE
Leukemia Inhibitory Factor Receptor alpha (LIFR) (AA 45-833) (Active) protein (Fc Tag)LIFR 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Leukemia Inhibitory Factor Receptor alpha (LIFR) (AA 45-154) protein (GST tag)LIFR 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Leukemia Inhibitory Factor Receptor alpha (LIFR) (Active) protein (His tag)LIFR 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
Leukemia Inhibitory Factor Receptor alpha (LIFR) (AA 859-1097) protein (His tag)Crystallography grade LIFR 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Leukemia Inhibitory Factor Receptor alpha (LIFR) (AA 854-1092) protein (His tag)Crystallography grade LIFR 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Leukemia Inhibitory Factor Receptor alpha (LIFR) (AA 45-833) protein (His tag)Crystallography grade LIFR 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Leukemia Inhibitory Factor Receptor alpha (LIFR) (AA 44-828) protein (His tag)Crystallography grade LIFR 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Leukemia Inhibitory Factor Receptor alpha (LIFR) (AA 45-1097) protein (rho-1D4 tag)Crystallography grade LIFR 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- LIFR (Leukemia Inhibitory Factor Receptor alpha (LIFR))
- 别名
- LIFR/CD118 (LIFR 产品)
- 别名
- A230075M04Rik Protein, AW061234 Protein, LIF Protein, CD118 Protein, LIF-R Protein, SJS2 Protein, STWS Protein, SWS Protein, leukemia inhibitory factor receptor Protein, LIF receptor alpha Protein, leukemia inhibitory factor receptor alpha Protein, Lifr Protein, LOC397451 Protein, LIFR Protein
- 背景
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Background: LIFR (leukemia inhibitory factor receptor) belongs to the family of cytokine receptors. LIFR forms a high-affinity receptor complex with gp130, which mediates the activity of LIF (leukemia inhibitory factor) and thus affects the differentiation, proliferation, and survival of a wide variety of cells in the adult and the embryo. Besides LIF, LIFR can also bind to and activate CNTF (ciliary neurotrophic factor) and CLC (cardiotrophin like cytokine). Evidence showed that in the retina, LIFR activating LIF, CT-1 and cardiotrophin like cytokine (CLC) are strongly upregulated in response to preconditioning with bright cyclic light leading to robust activation of signal transducer and activator of transcription-3 (STAT3) in a time-dependent manner. Further, blocking LIFR activation during preconditioning using a LIFR antagonist (LIF05) attenuated the induced STAT3 activation and also resulted in reduced preconditioning-induced protection of the retinal photoreceptors. These data demonstrate that LIFR and its ligands play an essential role in endogenous neuroprotective mechanisms triggered by preconditioning-induced stress. LIFR was newly found to be a suppressor of hepatocellular carcinoma (HCC), one of the world's top five causes of cancer-related deaths.
Synonym: A230075M04Rik,AW061234,LIF
- 分子量
- 90 kDa
- NCBI登录号
- NP_038612
- 途径
- JAK/STAT Signaling, Growth Factor Binding
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