LGALS8 Protein (GST tag)
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- 抗原 See all LGALS8 蛋白
- LGALS8 (Lectin, Galactoside-Binding, Soluble, 8 (LGALS8))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 大鼠
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资源
- 大肠杆菌(E. Coli)
- 标记
- This LGALS8 protein is labelled with GST tag.
- 原理
- Recombinant Rat Galectin-8/LGALS8 Protein (GST Tag)(Active)
- 序列
- Met 1-Trp 316
- 产品特性
- A DNA sequence encoding rat LGALS8 (NP_446314.2) (Met 1-Trp 316) was fused with the GST tag at the N-terminus.
- 纯度
- > 90 % as determined by SDS-PAGE
- Biological Activity Comment
- Measured by its ability to agglutinate human red blood cells.The ED50 for this effect is typically 0.05-0.3 μg/mL.
- Top Product
- Discover our top product LGALS8 蛋白
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, 10 % glycerol, 1 mM DTT, pH 8.0
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- LGALS8 (Lectin, Galactoside-Binding, Soluble, 8 (LGALS8))
- 别名
- Galectin-8/LGALS8 (LGALS8 产品)
- 别名
- LGALS8 Protein, 1200015E08Rik Protein, AI326142 Protein, D13Ertd524e Protein, Lgals-8 Protein, galectin-8 Protein, Gal-8 Protein, PCTA-1 Protein, PCTA1 Protein, Po66-CBP Protein, xgalectin-VIIIa Protein, galectin 8 Protein, lectin, galactose binding, soluble 8 Protein, lectin, galactoside binding soluble 8 S homeolog Protein, LGALS8 Protein, Lgals8 Protein, lgals8.S Protein
- 背景
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Background: The Galectin family of proteins, with specificity for Nacetyllactosaminecontaining glycoproteins, consists of beta-galactoside binding lectins containing homologous carbohydrate recognition domains (CRDs). They also possess hemagglutination activity, which is attributable to their bivalent carbohydrate binding properties. Galectins are active both intracellularly and extracellularly. Although they are localized primarily in the cytoplasm and lack a classical signal peptide, galectins can also be secreted by one or more unidentified, non-classical, secretory pathways. They have diverse effects on many cellular functions including adhesion, migration, polarity, chemotaxis, proliferation, apoptosis, and differentiation. Galectins may therefore play a key role in many pathological states, including autoimmune diseases, allergic reactions, inflammation, tumor cell metastasis, atherosclerosis, and diabetic complications. The galectins have been classified into the prototype galectins(1, 2, 5, 7, 10, 11, 13, 14), which contain one CRD and exist either as a monomer or a noncovalent homodimer. The chimera galectins(Galectin3) containing one CRD linked to a nonlectin domain, and the tandemrepeat Galectins(4, 6, 8, 9, 12) consisting of two CRDs joined by a linker peptide.Galectins lack a classical signal peptide and can be localized to the cytosolic compartments where they have intracellular functions. However, via one or more as yet unidentified nonclassical secretory pathways, galectins can also be secreted to function extracellularly. Individual members of the galectin family have different tissue distribution profiles and exhibit subtle differences in their carbohydrate-binding specificities. Each family member may preferentially bind to a unique subset of cell surface glycoproteins.
Synonym: 30 kDa S-type lectin,RL-30,gal-8,galectin-8,lectin,galactose binding,soluble 8
- 分子量
- 63.2 kDa
- NCBI登录号
- NP_446314
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