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Latexin Protein (LXN) (Fc Tag)

LXN 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by reducing SDS-PAGE.
产品编号 ABIN7196735
发货至: 中国
  • 抗原 See all Latexin (LXN) 蛋白
    Latexin (LXN)
    蛋白类型
    Recombinant
    宿主
    • 5
    • 3
    • 3
    资源
    • 7
    • 2
    • 1
    • 1
    HEK-293 Cells
    标记
    This Latexin protein is labelled with Fc Tag.
    原理
    Recombinant Human Latexin/LXN Protein (Fc Tag)
    序列
    Glu 2-Glu 222
    产品特性
    A DNA sequence encoding the human Latexin (NP_064554.3) (Glu 2-Glu 222) was fused with the Fc region of human IgG1 at the N-terminus.
    纯度
    > 90 % as determined by reducing SDS-PAGE.
    内毒素水平
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product LXN 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Please refer to the printed manual for detailed information.
    缓冲液
    Lyophilized from sterile 100 mM Glycine, 10 mM NaCl, 50 mM Tris, pH 7.5
    储存条件
    4 °C,-20 °C,-80 °C
    储存方法
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原
    Latexin (LXN)
    别名
    Latexin/LXN (LXN 产品)
    别名
    wu:fk66c02 Protein, zgc:103612 Protein, LXN Protein, lxn Protein, ECI Protein, TCI Protein, latexin Protein, lxn Protein, LXN Protein, Lxn Protein
    背景

    Background: Latexin; also known as endogenous carboxypeptidase inhibitor; tissue carboxypeptidase inhibitor; TCI; ECI and LXN; is a cytoplasm protein which belongs to the protease inhibitor I47 (latexin) family. It is highly expressed in heart; prostate; ovary; kidney; pancreas; and colon. Latexin / LXN is the only known endogenous specific inhibitor of zinc-dependent metallocarboxypeptidases (MCPs) present in mammalians so far. Latexin is originally identified as a molecular marker for the regional specification of the neocortex in development in rats. The 222 amino acid latexin in human shows different expression distribution with high levels in heart; prostate; ovary; kidney; pancreas; and colon; but only moderate or low levels in other tissues including brain. Latexin is also expressed at high levels and is inducible in macrophages in concert with other protease inhibitors and potential protease targets; and thus is suggested to play a role in inflammation and innate immunity pathways. Despite of the non-detectable sequence similarity with plant and parasite inhibitors; Latexin is related to a human putative tumor suppressor protein; TIG1. In addition; Latexin is also implicated in Alzheimer's disease.

    Synonym: ECI;TCI

    分子量
    52 kDa
    NCBI登录号
    NP_064554
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