Latexin Protein (LXN) (His tag)
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- 抗原 See all Latexin (LXN) 蛋白
- Latexin (LXN)
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 小鼠
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资源
- 大肠杆菌（E. Coli）
- 标记
- This Latexin protein is labelled with His tag.
- 原理
- Recombinant Mouse Latexin/LXN Protein (His Tag)(Active)
- 序列
- Glu 2-Glu 222
- 产品特性
- A DNA sequence encoding the mouse LXN (NP_058033.2) (Glu 2-Glu 222) was expressed, with a polyhistide tag at the N-terminus.
- 纯度
- > 95 % as determined by SDS-PAGE
- Biological Activity Comment
- Measured by its ability to inhibit carboxypeptidase-A1 cleavage of the colorimetric peptide substrate Ac-Phe-Thiaphe-OH in the presence of 5,5'Dithiobis(2-nitrobenzoic acid) (DTNB) (Edwards, K.M. et al, 1999, J. Biol. Chem. 274:30468). The IC50 value is <2.0 nM .
- Top Product
- Discover our top product LXN 蛋白
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Latexin (LXN) (AA 1-222) protein (GST tag)
LXN 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Latexin (LXN) (AA 151-222) protein (GST tag)LXN 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Latexin (LXN) proteinLXN 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % WB, SDS, ELISA, IP
Latexin (LXN) protein (Myc-DYKDDDDK Tag)LXN 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 8.0, 10 % glycerol
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- Latexin (LXN)
- 别名
- Latexin/LXN (LXN 产品)
- 别名
- wu:fk66c02 Protein, zgc:103612 Protein, LXN Protein, lxn Protein, ECI Protein, TCI Protein, latexin Protein, lxn Protein, LXN Protein, Lxn Protein
- 背景
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Background: Latexin, also known as endogenous carboxypeptidase inhibitor, tissue carboxypeptidase inhibitor, TCI, ECI and LXN, is a cytoplasm protein which belongs to the protease inhibitor I47 (latexin) family. It is highly expressed in heart, prostate, ovary, kidney, pancreas, and colon. Latexin / LXN is the only known endogenous specific inhibitor of zinc-dependent metallocarboxypeptidases (MCPs) present in mammalians so far. Latexin is originally identified as a molecular marker for the regional specification of the neocortex in development in rats. The 222 amino acid latexin in human shows different expression distribution with high levels in heart, prostate, ovary, kidney, pancreas, and colon, but only moderate or low levels in other tissues including brain. Latexin is also expressed at high levels and is inducible in macrophages in concert with other protease inhibitors and potential protease targets, and thus is suggested to play a role in inflammation and innate immunity pathways. Despite of the non-detectable sequence similarity with plant and parasite inhibitors, Latexin is related to a human putative tumor suppressor protein, TIG1. In addition, Latexin is also implicated in Alzheimer's disease.
Synonym: MGC144352, MGC144353
- 分子量
- 26.3 kDa
- NCBI登录号
- NP_058033
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