Kallikrein 4 Protein (His tag)
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- 抗原 See all Kallikrein 4 (KLK4) 蛋白
- Kallikrein 4 (KLK4) (Kallikrein-Related Peptidase 4 (KLK4))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This Kallikrein 4 protein is labelled with His tag.
- 原理
- Recombinant Human Kallikrein 4/KLK4 Protein (His Tag)(Active)
- 序列
- Met 1-Ser 254
- 产品特性
- A DNA sequence encoding the human KLK4 (NP_004908.3) (Met 1-Ser 254) was expressed, with a polyhistidine tag at the C-terminus.
- 纯度
- > 94 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to cleave the fluorogenic peptide substrate Boc-VPR-AMC. (R&D Systems, Catalog # ES011). The specific activity is >250 pmoles/min/μg.(Activation description: The proenzyme needs to be activated by Thermolysin for an activated form)
- Top Product
- Discover our top product KLK4 蛋白
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Kallikrein-Related Peptidase 4 (KLK4) (AA 1-254) protein (GST tag)
KLK4 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Kallikrein-Related Peptidase 4 (KLK4) (AA 159-254) protein (GST tag)KLK4 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Kallikrein-Related Peptidase 4 (KLK4) proteinKLK4 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % WB, SDS, ELISA, IP
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- Kallikrein 4 (KLK4) (Kallikrein-Related Peptidase 4 (KLK4))
- 别名
- Kallikrein 4/KLK4 (KLK4 产品)
- 别名
- ESMP1 Protein, KLK-L1 Protein, PSTS Protein, Prss17 Protein, AI2A1 Protein, ARM1 Protein, EMSP Protein, EMSP1 Protein, PRSS17 Protein, kallikrein Protein, Emsp1 Protein, kallikrein related-peptidase 4 (prostase, enamel matrix, prostate) Protein, kallikrein related peptidase 4 Protein, kallikrein-related peptidase 4 Protein, Klk4 Protein, KLK4 Protein
- 背景
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Background: Kallikrein-4, also known as Enamel matrix serine proteinase 1, Kallikrein-like protein 1, KLK-L1, Serine protease 17, KLK4, PRSS17 and EMSP1, is a secreted protein which belongs to the peptidase S1 family and Kallikrein subfamily. Kallikrein-4 / KLK4 is a serine protease expressed during enamel maturation, and proteolytic processing of the enamel matrix by KLK4 is critical for proper enamel formation. Kallikrein-4 / KLK4 contains one peptidase S1 domain. Kallikrein-4 / KLK4 is secreted by transition- and maturation-stage ameloblasts. KLK4 aggressively degrades the retained organic matrix following the termination of enamel protein secretion. Two proteases are secreted into the enamel matrix of developing teeth. The early protease is enamelysin (MMP-20). The late protease is kallikrein 4 (KLK4). The principle functions of MMP-20 and KLK4 in dental enamel formation are to facilitate the orderly replacement of organic matrix with mineral, generating an enamel layer that is harder, less porous, and unstained by retained enamel proteins. Defects in Kallikrein-4 / KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1) which is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions.
Synonym: Kallikrein-4; Enamel Matrix Serine Proteinase 1; Kallikrein-Like Protein 1; KLK-L1; Prostase; Serine Protease 17; KLK4; EMSP1; PRSS17; PSTS;AI2A1;ARM1;EMSP;kallikrein;KLK-L1
- 分子量
- 25.8 kDa
- NCBI登录号
- NP_004908
- 途径
- Complement System
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