IL4 Receptor Protein (His tag)
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- 抗原 See all IL4 Receptor (IL4R) 蛋白
- IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- Cynomolgus
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资源
- 人细胞
- 标记
- This IL4 Receptor protein is labelled with His tag.
- 原理
- Recombinant Cynomolgus Interleukin-4 Receptor Subunit Alpha/IL-4 Rα Protein (His Tag)
- 序列
- Met26-Arg232
- 产品特性
- Recombinant Cynomolgus IL-4 Rα is produced by our Mammalian expression system and the target gene encoding Met26-Arg232 is expressed with a 6His tag at the C-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Immobilized Human IL-4(Cat: PKSH033456) at 10μg/ml(100 μl/well) can bind Human IL-4Ra-His. The ED50 of Human IL-4Ra-His is 7μg/mL.
- Top Product
- Discover our top product IL4R 蛋白
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Interleukin 4 Receptor (IL4R) (AA 24-232) protein (Fc Tag)
IL4R 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 4 Receptor (IL4R) (AA 26-232) protein (His tag)IL4R 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 4 Receptor (IL4R) (AA 24-232) protein (His tag)IL4R 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 4 Receptor (IL4R) (AA 26-232) (Active) protein (Fc Tag)IL4R 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Interleukin 4 Receptor (IL4R) protein (His tag)IL4R 宿主: 小鼠 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
Interleukin 4 Receptor (IL4R) protein (Fc Tag)IL4R 宿主: 小鼠 宿主: 人细胞 Recombinant > 90 % as determined by reducing SDS-PAGE.
Interleukin 4 Receptor (IL4R) (AA 26-135) protein (GST tag)IL4R 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Interleukin 4 Receptor (IL4R) (Active) protein (His tag)IL4R 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
Interleukin 4 Receptor (IL4R) (Active) protein (Fc Tag)IL4R 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE Active
Interleukin 4 Receptor (IL4R) (AA 26-232) protein (His tag)Crystallography grade IL4R 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))
- 别名
- Interleukin-4 Receptor Subunit Alpha/IL-4 Ralpha (IL4R 产品)
- 别名
- IL4R Protein, il-4ra Protein, zgc:113063 Protein, CD124 Protein, IL-4RA Protein, IL4RA Protein, Il4ra Protein, IL4 Protein, Il4r Protein, interleukin 4 receptor Protein, interleukin 4 receptor, tandem duplicate 1 Protein, interleukin 4 receptor, alpha Protein, IL4R Protein, il4r.1 Protein, Il4r Protein, Il4ra Protein
- 背景
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Background: Interleukin-4 receptor subunit alpha(IL-4RA), alos known as Soluble IL-4 receptor subunit alpha, belongs to the type I cytokine receptor family and type 4 subfamily. It expressed in both Th1 and Th2 cells. It functions as receptor for both interleukin 4 and interleukin 13 and couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and chemokine and mucus production at sites of allergic inflammation. In certain cell types, IL-4RA can signal through activation of insulin receptor substrates, IRS1/IRS2. The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequently it recruits to the complex of the common gamma chain. In immune cells, IL-4RA creates a type I receptor. In non-immune cells, it forms a type II receptor with of IL13RA1. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor and interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP.
Synonym: Interleukin-4 receptor subunit alpha,IL-4R-alpha,CD124,IL4-BP,Soluble IL-4R-alpha
- 分子量
- 24.6 kDa
- UniProt
- G7Q0S7
- 途径
- JAK/STAT Signaling, Positive Regulation of Immune Effector Process
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