IL11RA Protein (His tag)
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- 抗原 See all IL11RA 蛋白
- IL11RA (Interleukin 11 Receptor, alpha (IL11RA))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This IL11RA protein is labelled with His tag.
- 原理
- Recombinant Mouse IL11RA/IL11Rα Protein (His Tag)(Active)
- 序列
- Met 1-Gln 367
- 产品特性
- A DNA sequence encoding the extracellular domain of mouse IL11Rα (NP_001156873.1) (Met 1-Gln 367) was expressed, with a C-terminal polyhistidine tag.
- 纯度
- > 85 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to bind mouse IL6ST in a functional ELISA.
- Top Product
- Discover our top product IL11RA 蛋白
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Interleukin 11 Receptor, alpha (IL11RA) (AA 24-370) protein (His tag)
IL11RA 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 11 Receptor, alpha (IL11RA) (AA 24-372) protein (His tag)IL11RA 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 11 Receptor, alpha (IL11RA) (AA 145-362) protein (His-IF2DI Tag)IL11RA 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Interleukin 11 Receptor, alpha (IL11RA) (AA 1-422) protein (GST tag)IL11RA 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Interleukin 11 Receptor, alpha (IL11RA) (AA 24-370) (Active) protein (Fc Tag)IL11RA 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- IL11RA (Interleukin 11 Receptor, alpha (IL11RA))
- 别名
- IL11RA/IL11Ralpha (IL11RA 产品)
- 别名
- CRSDA Protein, fi26e06 Protein, il-11ra Protein, wu:fi26e06 Protein, AI314697 Protein, GP130 Protein, Il-11ra Protein, Il11ra Protein, Il11ra2 Protein, NR1 Protein, interleukin 11 receptor subunit alpha Protein, interleukin 11 receptor, alpha Protein, interleukin 11 receptor subunit alpha 1 Protein, interleukin 11 receptor, alpha chain 1 Protein, IL11RA Protein, il11ra Protein, Il11ra1 Protein, Il11ra Protein
- 背景
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Background: Interleukin 11 receptor, alpha subunit (IL11RA/IL-11RA) is a subunit of the interleukin 11 receptor which is a member of the hematopoietic cytokine receptor family. IL11RA/IL-11RA is expressed in a number of cell lines, including the myelogenous leukemia cell line K562, the megakaryocytic leukemia cell line Mo7E, the erythroleukemia cell line TF1, and the osteosarcoma cell lines, MG-63 and Saos-2. It is also expressed in normal and malignant prostate epithelial cell lines. Expression levels are increased in prostate carcinoma. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus, and three variants encoding two different isoforms have been identified. IL11RA/IL-11RA is a receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. Defects in IL11RA/IL-11RA are a cause of craniosynostosis and dental anomalies (CRSDA). CRSDA is a disorder characterized by craniosynostosis, maxillary hypoplasia, and dental anomalies, including malocclusion, delayed and ectopic tooth eruption, and/or supernumerary teeth. Some patients also display minor digit anomalies, such as syndactyly and/or clinodactyly.
Synonym: AI314697,GP130,Il-11ra,Il11ra,Il11ra1,Il11ra2,NR1,RP23-167I12.2
- 分子量
- 39.2 kDa
- NCBI登录号
- NP_001156873
- 途径
- JAK/STAT Signaling, Growth Factor Binding
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