ILDR2 Protein (His tag)
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- 抗原 See all ILDR2 products
- ILDR2 (Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- 人细胞
- 标记
- This ILDR2 protein is labelled with His tag.
- 原理
- Recombinant Human ILDR2 (C-6His)
- 序列
- Leu21-Glu186
- 产品特性
- Recombinant Human Immunoglobulin-like Domain-containing Receptor 2 is produced by our Mammalian expression system and the target gene encoding Leu21-Glu186 is expressed with a 6His tag at the C-terminus.
- 纯度
- >95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- ILDR2 (Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2))
- 别名
- ILDR2 (ILDR2 产品)
- 别名
- C1orf32 Protein, RP4-782G3.2 Protein, dJ782G3.1 Protein, immunoglobulin like domain containing receptor 2 Protein, ILDR2 Protein
- 背景
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Background: ILDR2 is a member of the B7-like family of proteins that regulate T cell activity, is also a known endoplasmic reticulum molecule that regulates lipid homeostasis. The human ILDR2 lumenal domain shares a 99 % and 98 % homology with the mouse and rat respectively. The human gene encoding ILDR2 is located in a region on Chr1q23-25 that has been associated with type 2 diabetes. ILDR2 plays critical roles in hepatic clearance of lipoproteins and in lipid homeostasis. ILDR2 regulates human dendritic cells (DC2 cells, a subpopulation of polarized DCs that promotes Th2 differentiation). Recent publications reported that ILDR2 displayed negative regulatory functions on human and mouse T cells in various experimental systems. Fusion protein of ILDR2 lumenal domain with an Fc fragment, displays therapeutic effects in collagen-induced arthritis (CIA), a mouse model of rheumatoid arthritis (RA). ILDR2 represents a novel B7-like ligand that exerts negative immune modulation via interaction with a putative counterpart receptor expressed on activated T cells.
Synonym: Angulin-3, C1orf32, Dbsm1, DJ782G3.1, ILDR2, immunoglobulin-like domain containing receptor 2, LISCH-Like
- 分子量
- 19.5 kDa
- UniProt
- Q71H61
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