ILDR2 Protein (AA 21-186) (Fc Tag)
-
- 抗原 See all ILDR2 products
- ILDR2 (Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2))
- 蛋白类型
- Recombinant
- 产品特性
- AA 21-186
-
宿主
- 人
-
资源
- HEK-293 Cells
- 标记
- This ILDR2 protein is labelled with Fc Tag.
- 产品特性
- Human ILDR2 Protein, Fc Tag
- 纯度
- >95 % as determined by SDS-PAGE.
- 内毒素水平
- Less than 1.0 EU per μg by the LAL method.
-
Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2) (AA 21-184) protein (Fc Tag)
ILDR2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 92 % as determined by HPLC
Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2) protein (His tag)ILDR2 宿主: 人 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2) (AA 1-186), (Extracellular) protein (GST tag)ILDR2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2) (AA 1-186), (Extracellular) protein (His tag)ILDR2 宿主: 人 宿主: 酵母菌 Recombinant > 90 % SDS
-
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 缓冲液
- PBS, pH 7.4
- 储存条件
- -20 °C
-
- 抗原
- ILDR2 (Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2))
- 别名
- ILDR2 (ILDR2 产品)
- 别名
- C1orf32 Protein, RP4-782G3.2 Protein, dJ782G3.1 Protein, immunoglobulin like domain containing receptor 2 Protein, ILDR2 Protein
- 背景
- ILDR2 belongs to the immunoglobulin superfamily. May be involved in lipid homeostasis and ER stress pathways. ILDR2 as a novel B7-like protein with robust T cell inhibitory activity, expressed in immune cells and in immune-privileged and inflamed tissues. A fusion protein, consisting of ILDR2 extracellular domain with an Fc fragment, that binds to a putative counterpart on activated T cells showed a beneficial effect in the collagen-induced arthritis model and abrogated the production of proinflammatory cytokines and chemokines in autologous synovial-like cocultures of macrophages and cytokine-stimulated T cells. Collectively, these findings point to ILDR2 as a novel negative regulator for T cells, with potential roles in the development of immune-related diseases, including autoimmunity and cancer.
- 分子量
- 45.1 kDa
- NCBI登录号
- NP_955383
-
