GFRA3 Protein (His tag,Fc Tag)
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- 抗原 See all GFRA3 蛋白
- GFRA3 (GDNF Family Receptor alpha 3 (GFRA3))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This GFRA3 protein is labelled with His tag,Fc Tag.
- 原理
- Recombinant Human GFRA3/GFR-alpha-3 Protein (His & Fc Tag)(Active)
- 序列
- Met 1-Trp 382
- 产品特性
- A DNA sequence encoding the human GFRa3 (NP_001487.2) (Met 1-Trp 382) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
- 纯度
- > 80 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to bind mouse ARTN in a functional ELISA.
- Top Product
- Discover our top product GFRA3 蛋白
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GDNF Family Receptor alpha 3 (GFRA3) (AA 32-382) protein (His tag)
GFRA3 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
GDNF Family Receptor alpha 3 (GFRA3) (AA 29-379) protein (His tag)GFRA3 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
GDNF Family Receptor alpha 3 (GFRA3) (AA 1-400) protein (GST tag)GFRA3 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
GDNF Family Receptor alpha 3 (GFRA3) protein (Fc Tag)GFRA3 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE
GDNF Family Receptor alpha 3 (GFRA3) (AA 32-374) protein (His tag)Crystallography grade GFRA3 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB, Crys
GDNF Family Receptor alpha 3 (GFRA3) (AA 29-371) protein (His tag)Crystallography grade GFRA3 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB, Crys
GDNF Family Receptor alpha 3 (GFRA3) (AA 32-374) protein (His tag)GFRA3 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 85 % by SDS - PAGE SDS
GDNF Family Receptor alpha 3 (GFRA3) (AA 32-374) protein (hIgG-His-tag)GFRA3 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 85 % by SDS - PAGE SDS
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.5
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- GFRA3 (GDNF Family Receptor alpha 3 (GFRA3))
- 别名
- GFRA3/GFR-alpha-3 (GFRA3 产品)
- 别名
- GFRA3 Protein, GFRalpha3 Protein, Y15110 Protein, GDNF family receptor alpha 3 Protein, glial cell line derived neurotrophic factor family receptor alpha 3 Protein, Gfra3 Protein, GFRA3 Protein
- 背景
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Background: Glial cell line derived neurotrophic factor (GDNF) Family Receptor Alpha 3 (GFRA3) or GDNFRa3 is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. GFRA3 / GDNFRa3 is a potent survival factor for central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are its binding ligand which are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GDNF promotes the formation of a physical complex between GFRA/GDNFRa and the orphan tyrosin kinase receptor Ret, thereby inducing its tyrosine phosphorylation. The RET is a receptor tyrosine kinase representing the signal-transducing molecule of a multisubunit surface receptor complex for the GDNF, in which GFRA / GDNFRa acts as the ligand-binding component. The neurotrophic growth factor artemin binds selectively to GDNF family receptor α3 (GFRA3 / GDNFRa3), forming a molecular complex with the co-receptor RET which mediates downstream signaling. This signaling pathway has been demonstrated to play an important role in the survival and maintenance of nociceptive sensory neurons and in the development of sympathetic neurons.
Synonym: GDNFR3
- 分子量
- 67.3 kDa
- NCBI登录号
- NP_001487
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