Follistatin Protein (FST) (Fc Tag)
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- 抗原 See all Follistatin (FST) 蛋白
- Follistatin (FST)
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This Follistatin protein is labelled with Fc Tag.
- 原理
- Recombinant Human Follistatin/FST Protein (Fc Tag)(Active)
- 序列
- Met 1-Trp 344
- 产品特性
- A DNA sequence encoding the human FST isoform FST344 (NP_037541.1) (Met 1-Trp 344) was fused with the Fc region of human IgG1 at the C-terminus.
- 纯度
- > 85 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- 1. Measured by its ability to bind human INHBA-his in a functional ELISA.2. Measured by its ability to bind mouse INHBA-his in a functional ELISA.3. Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation. The ED50 for this effect is typically 0.5-3 μg/mL in the presence of 10 ng/ml Recombinant Human ctivin A.
- Top Product
- Discover our top product FST 蛋白
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- Follistatin (FST)
- 别名
- Follistatin/FST (FST 产品)
- 别名
- CG12955 Protein, CG12956 Protein, CG33466 Protein, Dmel\\CG33466 Protein, Fol1 Protein, dFS Protein, dFol1 Protein, dfs Protein, fs Protein, FS Protein, foll Protein, xfs Protein, FST Protein, fst Protein, AL033346 Protein, FOL1 Protein, Fst-288 Protein, RATFOL1 Protein, cb446 Protein, fd07h10 Protein, fst1 Protein, wu:fd07h10 Protein, Follistatin Protein, follistatin Protein, follistatin L homeolog Protein, follistatin a Protein, Fs Protein, fst Protein, FST Protein, LOC100141662 Protein, fst.L Protein, Fst Protein, fsta Protein
- 背景
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Background: Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. follistatin are expressed and subserve local regulatory roles in numerous extragonadal tissues, including brain, adrenal, bone marrow, and placenta but perhaps most notably in anterior pituitary-the classical target tissue for inhibin, the activin-follistatin system may play a key role in early embryogenesis. Follistatin binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone follistatin is a binding protein to activin. Since activin binds to follistatin, it is imperative to determine the nature of the activin/follistatin binding complex.
Synonym: FS
- 分子量
- 61.7 kDa
- NCBI登录号
- NP_037541
- 途径
- Negative Regulation of Hormone Secretion
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