FCN1 Protein (His tag)
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- 抗原 See all FCN1 蛋白
- FCN1 (Ficolin (Collagen/fibrinogen Domain Containing) 1 (FCN1))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This FCN1 protein is labelled with His tag.
- 原理
- Recombinant Human Ficolin-1/Ficolin-A/FCN1 Protein (His Tag)(Active)
- 序列
- Met 1-Ala 326
- 产品特性
- A DNA sequence encoding the human FCN1 (NP_001994.2) precursor (Met 1-Ala 326) was expressed with a C-terminal polyhistidine tag.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Measured by its binding ability in a functional ELISA.1. Immobilized FCN1 at 10 μg/ml can bind biotinylated recombinant human Fetuin-A with a linear range of 16-2000 ng/ml.2. Immobilized FCN1 at 10 μg/ml can bind biotinylated recombinant mouse Fetuin-A with a linear range of 16-2000 ng/ml.
- Top Product
- Discover our top product FCN1 蛋白
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Ficolin (Collagen/fibrinogen Domain Containing) 1 (FCN1) (AA 1-326) protein (GST tag)
FCN1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Ficolin (Collagen/fibrinogen Domain Containing) 1 (FCN1) (AA 201-300) protein (GST tag)FCN1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Ficolin (Collagen/fibrinogen Domain Containing) 1 (FCN1) (AA 30-326) protein (His tag)Crystallography grade FCN1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Ficolin (Collagen/fibrinogen Domain Containing) 1 (FCN1) (AA 18-334) protein (His tag)Crystallography grade FCN1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Ficolin (Collagen/fibrinogen Domain Containing) 1 (FCN1) proteinFCN1 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % WB, SDS, ELISA, IP
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- FCN1 (Ficolin (Collagen/fibrinogen Domain Containing) 1 (FCN1))
- 别名
- Ficolin-1/Ficolin-A/FCN1 (FCN1 产品)
- 别名
- FCNM Protein, FCNB Protein, FCN2 Protein, FCN1 Protein, ficolin 1 Protein, ficolin (collagen/fibrinogen domain containing) 1 Protein, ficolin-1 Protein, FCN1 Protein, Fcn1 Protein, LOC100069029 Protein
- 背景
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Background: Ficolins are humoral molecules of the innate immune systems which recognize carbohydrate molecules on pathogens, apoptotic and necrotic cells. The Ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. Ficolins are humoral molecules of the innate immune systems which recognize carbohydrate molecules on pathogens, apoptotic and necrotic cells. Three Ficolins have been identified in humans: L-Ficolin, H-Ficolin and M-Ficolin (also referred to as Ficolin-2, -3 and -1, respectively). They are soluble oligomeric defence proteins with lectin-like activity and they are structurally similar to the human collectins, mannan-binding lectin (MBL) and surfactant protein A and D. Dysfunction or abnormal expressions of Ficolins may involved in the pathogenesis of human diseases including infectious and inflammatory diseases, autoimmune disease and clinical syndrome of preeclampsia. They are soluble oligomeric defence proteins with lectin-like activity and they are structurally similar to the human collectins, mannan-binding lectin (MBL) and surfactant protein A and D. Upon recognition of the infectious agent, the Ficolins act through two distinct routes: initiate the lectin pathway of complement activation through attached serine proteases (MASPs), and a primitive opsonophagocytosis thus limiting the infection and concurrently orchestrating the subsequent adaptive clonal immune response. Ficolin-1 (FCN1) is predominantly expressed in the peripheral blood leukocytes.
Synonym: FCN1,FCNA,FCNM
- 分子量
- 33.6 kDa
- NCBI登录号
- NP_001994
- 途径
- Complement System
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