FGFRL1 Protein (His tag)
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- 抗原 See all FGFRL1 蛋白
- FGFRL1 (Fibroblast Growth Factor Receptor-Like 1 (FGFRL1))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This FGFRL1 protein is labelled with His tag.
- 原理
- Recombinant Mouse FGFRL1/FGFR5 Protein (His Tag)(Active)
- 序列
- Met 1-Pro 374
- 产品特性
- A DNA sequence encoding the extracellular domain of mouse FGFRL1 (NP_473412.1) (Met 1-Pro 374) precursor was expressed, with a C-terminal polyhistidine tag.
- 纯度
- > 90 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Measured by its binding ability in a functional ELISA.1. Immobilized mouse at 10 μg/ml (100 μl/well) can bind mouse FGFR5. The EC50 of mouse FGFR5 is 0.34 μg/ml.2. Immobilized human FGF1 at 10 μg/ml (100 μl/well) can bind mouse FGFR5 with a linear range of 0.08-2 μg/ml.3. Immobilized human bFGF at 5 μg/ml (100 μl/well) can bind mouse FGFR5. The EC50 of mouse FGFR5 is 0.22 μg/ml.
- Top Product
- Discover our top product FGFRL1 蛋白
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Fibroblast Growth Factor Receptor-Like 1 (FGFRL1) (AA 121-230) protein (GST tag)
FGFRL1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Fibroblast Growth Factor Receptor-Like 1 (FGFRL1) (AA 1-504) protein (GST tag)FGFRL1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Fibroblast Growth Factor Receptor-Like 1 (FGFRL1) (AA 25-378) protein (His tag)Crystallography grade FGFRL1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Fibroblast Growth Factor Receptor-Like 1 (FGFRL1) (AA 400-504) protein (His tag)Crystallography grade FGFRL1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Fibroblast Growth Factor Receptor-Like 1 (FGFRL1) (AA 21-374) protein (His tag)Crystallography grade FGFRL1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Fibroblast Growth Factor Receptor-Like 1 (FGFRL1) (AA 396-529) protein (His tag)Crystallography grade FGFRL1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Fibroblast Growth Factor Receptor-Like 1 (FGFRL1) (AA 25-504) protein (rho-1D4 tag)Crystallography grade FGFRL1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Fibroblast Growth Factor Receptor-Like 1 (FGFRL1) (AA 21-529) protein (rho-1D4 tag)Crystallography grade FGFRL1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- FGFRL1 (Fibroblast Growth Factor Receptor-Like 1 (FGFRL1))
- 别名
- FGFRL1/FGFR5 (FGFRL1 产品)
- 别名
- fgfrl1 Protein, zgc:64084 Protein, FGFR5 Protein, FGFR5beta Protein, FGFR5gamma Protein, Fgfr5 Protein, FHFR Protein, XFGFRL1 Protein, Xndk Protein, fgfrl1-a Protein, fgfrl1-b Protein, ndk Protein, im:7154242 Protein, fibroblast growth factor receptor like 1a Protein, fibroblast growth factor receptor-like 1 Protein, fibroblast growth factor receptor like 1 Protein, fibroblast growth factor receptor like 1 L homeolog Protein, fibroblast growth factor receptor like 1b Protein, fgfrl1a Protein, Fgfrl1 Protein, FGFRL1 Protein, fgfrl1.L Protein, fgfrl1b Protein
- 背景
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Background: Fibroblast growth factor receptor-like 1 (FGFRL1) also known as Fibroblast growth factor receptor 5 (FGFR5), is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A unique feature of FGFRL1/FGFR5 is that it does not contain an intracellular tyrosine kinase domain. Some muscle types, including the muscles of the tongue and the diaphragm, express FGFRL1/FGFR5 at relatively high level. In contrast, the heart and the skeletal muscles of the limbs, as well as many other organs (brain, lung, liver, kidney, gut) express Fgfrl1 only at basal level. It is conceivable that FGFRL1/FGFR5 interacts with other Fgfrs, which are expressed in cartilage and muscle, to modulate FGF signaling.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: FGFR5;FGFR5beta;FGFR5gamma
- 分子量
- 40.4 kDa
- NCBI登录号
- NP_473412
- 途径
- RTK signaling
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