FGFR2 Protein (AA 400-821) (GST tag,His tag)
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- 抗原 See all FGFR2 蛋白
- FGFR2 (Fibroblast Growth Factor Receptor 2 (FGFR2))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 400-821
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宿主
- 人
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资源
- Baculovirus infected Insect Cells
- 标记
- This FGFR2 protein is labelled with GST tag,His tag.
- 原理
- Recombinant Human FGFR2/CD332 Protein (aa 400-821, His & GST Tag)(Active)
- 序列
- Met 400-Thr 821
- 产品特性
- A DNA sequence encoding the human FGFR2 (NP_000132.3) cytoplasmic domain (Met 400-Thr 821) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- 纯度
- > 92 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- 1.The specific activity was determined to be 28 nmol/min/mg using Poly(Glu:Tyr) 4:1 as substrate.2. Measured by its binding ability in a functional ELISA. Immobilized recombinant human FGFR2 (aa 400-821) at 10 μg/ml (100 μl/well) can bind biotinylated human FGF acidic with a linear range of 15.6-250 ng/ml.3. Measured by its binding ability in a functional ELISA. Immobilized recombinant recombinant human FGFR2 (aa 400-821) at 10 μg/ml (100 μl/well) can bind biotinylated human FGF basic with a linear range of 0.16-1.25 μg/ml.
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Fibroblast Growth Factor Receptor 2 (FGFR2) (AA 399-821) protein (His tag)Crystallography grade FGFR2 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Frozen, Liquid
- 缓冲液
- Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol
- 储存条件
- -20 °C
- 储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- 抗原
- FGFR2 (Fibroblast Growth Factor Receptor 2 (FGFR2))
- 别名
- FGFR2/CD332 (FGFR2 产品)
- 别名
- FGFR2 Protein, FGFR2IIIb Protein, bek Protein, bfr-1 Protein, cd332 Protein, cek3 Protein, cfd1 Protein, ect1 Protein, fgfr-2 Protein, jws Protein, k-sam Protein, kgfr Protein, tk14 Protein, tk25 Protein, xfgfr2 Protein, DKFZp469H1521 Protein, BBDS Protein, BEK Protein, BFR-1 Protein, CD332 Protein, CEK3 Protein, CFD1 Protein, ECT1 Protein, JWS Protein, K-SAM Protein, KGFR Protein, TK14 Protein, TK25 Protein, AU043015 Protein, AW556123 Protein, Bek Protein, Fgfr-2 Protein, Fgfr-7 Protein, Fgfr7 Protein, KGFRTr Protein, svs Protein, FGF-R Protein, fgfr72IIIb Protein, FGFR Protein, fc56c05 Protein, wu:fc56c05 Protein, fibroblast growth factor receptor 2 Protein, fibroblast growth factor receptor 2 L homeolog Protein, FGFR2 Protein, LOC100084641 Protein, fgfr2 Protein, Fgfr2 Protein, fgfr2.L Protein
- 背景
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Background: FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. It is required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. FGFR2 plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. It also promotes cell proliferation in keratinocytes and imature osteoblasts, but promotes apoptosis in differentiated osteoblasts. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal CD332 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. Defects in CD3322 are the cause of Crouzon syndrome, Jackson-Weiss syndrome, Apert syndrome, Pfeiffer syndrome, Beare-Stevenson cutis gyrata syndrome, familial scaphocephaly syndrome, lacrimo-auriculo-dento-digital syndrome and Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: BBDS;BEK;BFR-1;CD332;CEK3;CFD1;ECT1;JWS;K-SAM;KGFR;TK14;TK25
- 分子量
- 75.7 kDa
- NCBI登录号
- NP_000132
- 途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Growth Factor Binding
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