EPH Receptor B1 Protein (EPHB1) (AA 565-984) (GST tag,His tag)
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- 抗原 See all EPH Receptor B1 (EPHB1) 蛋白
- EPH Receptor B1 (EPHB1)
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 565-984
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宿主
- 人
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资源
- Baculovirus infected Insect Cells
- 标记
- This EPH Receptor B1 protein is labelled with GST tag,His tag.
- 原理
- Recombinant Human EphB1/EPHT2 Protein (aa 565-984, His & GST Tag)(Active)
- 序列
- Arg565-Ala984
- 产品特性
- A DNA sequence encoding the human EPHB1 (AAI11745.1) (Arg565-Ala984) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- The specific activity was determined to be 140 nmol/min/mg using Poly(Glu:Tyr) 4:1 as substrate.
- Top Product
- Discover our top product EPHB1 蛋白
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EPH Receptor B1 (EPHB1) (AA 221-320) protein (GST tag)
EPHB1 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
EPH Receptor B1 (EPHB1) (Active) protein (GST tag,His tag)EPHB1 宿主: 小鼠 宿主: Baculovirus infected Insect Cells Recombinant > 80 % as determined by SDS-PAGE Active
EPH Receptor B1 (EPHB1) protein (Fc Tag)EPHB1 宿主: 人 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
EPH Receptor B1 (EPHB1) (Active) protein (His tag)EPHB1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 98 % as determined by SDS-PAGE Active
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- 限制
- 仅限研究用
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- 状态
- Frozen, Liquid
- 缓冲液
- Supplied as sterile 20 mM Tris, 500 mM NaCl, 3 mM DTT, pH 8.0, 10 % glycerol
- 储存条件
- -20 °C
- 储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- 抗原
- EPH Receptor B1 (EPHB1)
- 别名
- EphB1/EPHT2 (EPHB1 产品)
- 别名
- ELK Protein, EPHT2 Protein, Hek6 Protein, NET Protein, ephb1-a Protein, xek Protein, Xek Protein, MGC89790 Protein, EPHB1 Protein, CEK6 Protein, EK6 Protein, 9330129L11 Protein, AW488255 Protein, C130099E04Rik Protein, Cek6 Protein, ENSMUSG00000074119 Protein, Elk Protein, Elkh Protein, Net Protein, Ephb2 Protein, Erk Protein, elk Protein, EPH receptor B1 Protein, EPH receptor B1 S homeolog Protein, ephrin type-B receptor 1 Protein, Eph receptor B1 Protein, EPHB1 Protein, ephb1.S Protein, ephb1 Protein, LOC100467687 Protein, Ephb1 Protein
- 背景
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Background: Ephrin type-B receptor 1, also known as EphB1, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. EphB2 receptor tyrosine kinase phosphorylates syndecan-2 and that this phosphorylation event is crucial for syndecan-2 clustering and spine formation. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. EphB receptor tyrosine kinases are enriched at synapses, suggesting that these receptors play a role in synapse formation or function. We find that EphrinB binding to EphB induces a direct interaction of EphB with NMDA-type glutamate receptors. This interaction occurs at the cell surface and is mediated by the extracellular regions of the two receptors, but does not require the kinase activity of EphB.
Synonym: Ephrin Type-A Receptor 7, EPH Homology Kinase 3, EHK-3, EPH-Like Kinase 11, EK11, hEK11, EPHA7, EHK3, HEK11
- 分子量
- 75.3 kDa
- 途径
- RTK signaling
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