EPH Receptor A8 Protein (EPHA8) (His tag)
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- 抗原 See all EPH Receptor A8 (EPHA8) 蛋白
- EPH Receptor A8 (EPHA8)
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- 人细胞
- 标记
- This EPH Receptor A8 protein is labelled with His tag.
- 原理
- Recombinant Human EphA8 (C-6His)
- 序列
- Glu31--Thr542
- 产品特性
- Recombinant Human Ephrin type-A receptor 8 is produced by our Mammalian expression system and the target gene encoding Glu31-Thr542 is expressed with a 6His tag at the C-terminus.
- 纯度
- >95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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EPH Receptor A8 (EPHA8) protein (Fc Tag)
EPHA8 宿主: 人 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
EPH Receptor A8 (EPHA8) protein (DYKDDDDK-His Tag)EPHA8 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- EPH Receptor A8 (EPHA8)
- 别名
- EphA8 (EPHA8 产品)
- 别名
- TK Protein, tke17-a Protein, si:ch211-122l14.1 Protein, EPHA8 Protein, EEK Protein, EK3 Protein, HEK3 Protein, AW047546 Protein, Eek Protein, Hek3 Protein, mKIAA1459 Protein, EPH receptor A8 L homeolog Protein, EPH receptor A8 Protein, eph receptor A8 Protein, Eph receptor A8 Protein, epha8.L Protein, EPHA8 Protein, epha8 Protein, Epha8 Protein
- 背景
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Background: EphA8, also known as Hek3 and Eek, is a 120 kDa glycosylated member of the Eph family of transmembrane receptor tyrosine kinases. The A and B classes of Eph proteins are distinguished by Ephrin ligand binding preference but have a common structural organization. Eph-Ephrin interactions are widely involved in the regulation of cell migration, tissue morphogenesis, and cancer progression. Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth.
Synonym: EEK, EK3, HEK3, EPH- and ELK-related kinase, EPH- and ELK-related tyrosine kinase, EPH receptor A8, EphA8, EPH-like kinase 3, ephrin type-A receptor 8, Hek3
- 分子量
- 57.4 kDa
- UniProt
- P29322
- 途径
- RTK signaling
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