DDC Protein (His tag)
-
- 抗原 See all DDC 蛋白
- DDC (Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC))
- 蛋白类型
- Recombinant
- 生物活性
- Active
-
宿主
- 人
-
资源
- Baculovirus infected Insect Cells
- 标记
- This DDC protein is labelled with His tag.
- 原理
- Recombinant Human DOPA Decarboxylase/DDC Protein (His Tag)(Active)
- 序列
- Met 1-Glu 480
- 产品特性
- A DNA sequence encoding the full length of human DDC (NP_000781.1) (Met 1-Glu 480) was expressed with a polyhistidine tag at the C-terminus.
- 纯度
- > 90 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to convert the substrate 3, 4-dihydroxy L-phenylalanine (L-Dopa) to 3, 4-dihydroxyphenylethylamine (dopamine). The dopamine product is measured by its absorbance at 340 nm after derivatization with trinitrobenzene sulfonic acid. The specific activity is >1000 pmoles/min/μg.
- Top Product
- Discover our top product DDC 蛋白
-
Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC) (AA 1-480) protein (His tag)
DDC 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % by SDS - PAGE SDS
Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC) (AA 296-401) protein (His-IF2DI Tag)DDC 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC) (AA 1-480) protein (GST tag)DDC 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC) (AA 371-480) protein (GST tag)DDC 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC) protein (His tag)DDC 宿主: 小鼠 宿主: Baculovirus infected Insect Cells Recombinant > 90 % as determined by SDS-PAGE
Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)DDC 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
-
- 限制
- 仅限研究用
-
- 状态
- Frozen, Liquid
- 缓冲液
- Supplied as sterile 50 mM Tris, 100 mM NaCl, pH 8, 10 % glycerol
- 储存条件
- -20 °C
- 储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
-
- 抗原
- DDC (Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC))
- 别名
- DOPA Decarboxylase/DDC (DDC 产品)
- 别名
- AADC Protein, wu:fa56d05 Protein, wu:fd59h03 Protein, wu:fk20h01 Protein, zgc:65801 Protein, zgc:76929 Protein, Ddc Protein, DdcDv Protein, Dvir\\GJ17995 Protein, GJ17995 Protein, dvir_GLEANR_2561 Protein, Aadc Protein, 5-HT Protein, CG10697 Protein, DDC Protein, DdcDm Protein, Dmel\\CG10697 Protein, ddc Protein, fDDC Protein, l(2)37Bl Protein, l(2)37Ch Protein, l(2)k02104 Protein, dopa decarboxylase Protein, Dopa-decarboxylase Protein, dopa decarboxylase (aromatic L-amino acid decarboxylase) Protein, Dopa decarboxylase Protein, dopa decarboxylase L homeolog Protein, DDC Protein, ddc Protein, Ddc Protein, Dvir\Ddc Protein, ddc.L Protein
- 背景
-
Background: Dopa Decarboxylase (DDC), also known as AADC and Aromatic-L-amino acid decarboxylase, is a 54 kDa member of the group II decarboxylase family of proteins.It is a vitamin B6-dependent homodimeric enzyme that catalyzes the decarboxylation of both L-3,4-dihydroxyphenylalanine (L-DOPA) and L-5-hydroxytryptophan to dopamine and serotonin, respectively, which are major mammalian neurotransmitters and hormones belonging to catecholamines and indoleamines. Since L-DOPA is regularly used to treat the symptoms of Parkinson's disease, the catalytic pathway is of particular research interest. Defects of DDC are associated with severe developmental delay, oculogyric crises (OGC), as well as autosomal recessive disorder AADC deficiency, an early onset inborn error in neurotransmitter metabolism which can lead to catecholamine and serotonin deficiency.
Synonym: AADC
- 分子量
- 55 kDa
- NCBI登录号
- NP_000781
- 途径
- Dopaminergic Neurogenesis
-
