DMP1 Protein (His tag)
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- 抗原 See all DMP1 (DMTF1) 蛋白
- DMP1 (DMTF1) (Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This DMP1 protein is labelled with His tag.
- 原理
- Recombinant Human DMP1 Protein (His Tag)(Active)
- 序列
- Met 1-Tyr 513
- 产品特性
- A DNA sequence encoding the human DMP1 (Q13316-1) (Met 1-Tyr 513) was expressed, with a polyhistidine tag at the C-terminus.
- 纯度
- > 85 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to bind human CFH in a functional ELISA.
- Top Product
- Discover our top product DMTF1 蛋白
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Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1) (AA 221-330) protein (GST tag)
DMTF1 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1) (AA 661-760) protein (GST tag)DMTF1 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1) (AA 1-760) protein (Strep Tag)Crystallography grade DMTF1 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1) (AA 1-761) protein (Strep Tag)Crystallography grade DMTF1 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1) (AA 17-513) protein (His tag)Crystallography grade DMTF1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1) (AA 17-503) protein (His tag)Crystallography grade DMTF1 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)DMTF1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- DMP1 (DMTF1) (Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1))
- 别名
- DMP1 (DMTF1 产品)
- 别名
- DMP1 Protein, DMTF Protein, hDMP1 Protein, Dimp Protein, Dmp1 Protein, DMTF1 Protein, zgc:92448 Protein, cyclin D binding myb like transcription factor 1 Protein, cyclin D binding myb-like transcription factor 1 Protein, DMTF1 Protein, Dmtf1 Protein, dmtf1 Protein
- 背景
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Background: Dentin matrix acidic phosphoprotein (DMP1) is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. DMP1 contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation, DMP1 becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in DMP1 are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. DMP1 may have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite.
Synonym: Dentin Matrix Acidic Phosphoprotein 1, DMP-1, Dentin Matrix Protein 1, DMP1,ARHP,ARHR
- 分子量
- 55.4 kDa
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