CMA1 Protein (His tag)
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- 抗原 See all CMA1 蛋白
- CMA1 (Chymase 1, Mast Cell (CMA1))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- Baculovirus infected Insect Cells
- 标记
- This CMA1 protein is labelled with His tag.
- 原理
- Recombinant Human CMA1/Chymase 1 Protein (His Tag)
- 序列
- Met 1-Asn 247
- 产品特性
- A DNA sequence encoding the human CMA1 (P23946) (Met 1-Asn 247) was fused with a polyhistidine tag at the C-terminus.
- 纯度
- > 92 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Top Product
- Discover our top product CMA1 蛋白
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Chymase 1, Mast Cell (CMA1) (AA 22-247) protein (His tag)
Crystallography grade CMA1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Chymase 1, Mast Cell (CMA1) (AA 22-247) protein (His tag)Crystallography grade CMA1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Chymase 1, Mast Cell (CMA1) (AA 22-249), (full length) protein (His tag)CMA1 宿主: 犬 宿主: 酵母菌 Recombinant > 90 % ELISA
Chymase 1, Mast Cell (CMA1) proteinCMA1 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % SDS, WB, ELISA, IP
Chymase 1, Mast Cell (CMA1) (AA 22-146), (partial) protein (His tag)CMA1 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
Chymase 1, Mast Cell (CMA1) (AA 22-249) protein (His-SUMO Tag)CMA1 宿主: 犬 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
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- 限制
- 仅限研究用
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- 状态
- Frozen, Liquid
- 缓冲液
- Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol
- 储存条件
- -20 °C
- 储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- 抗原
- CMA1 (Chymase 1, Mast Cell (CMA1))
- 别名
- CMA1/Chymase 1 (CMA1 产品)
- 别名
- CYH Protein, MCT1 Protein, chymase Protein, MMCP-5 Protein, Mcp-5 Protein, Mcp5 Protein, Mcpt5 Protein, MCP3P Protein, CMA1 Protein, Chymase Protein, chymase 1 Protein, chymase 1, mast cell Protein, chymase-like Protein, CMA1 Protein, Cma1 Protein, LOC100008644 Protein
- 背景
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Background: Chymotrypsin C (abbreviated for CTRC), also known as caldecrin or elastase4, is a digestive enzyme of the peptidase S1 family. This enzyme is synthesized as an inactivate chymotrypsinogen. On cleavage by trypsin into two parts that activate each other by removing two small peptides in a trans-proteolysis, chymotrypsin C produced. N-linked glycosylation of human CTRC is required for efficient folding and secretion, however, the N-linked glycan is unimportant for enzyme activity or inhibitor binding. It has been proposed that CTRC is a key regulator of digestive zymogen activation and a physiological co-activator of digestive carboxypeptidases proCPA1 and proCPA2. Mutations that abolish activity or secretion of CTRC increase the risk for chronic pancreatitis. It's speculated that CTRC might regulate pancreatic cancer cell migration in relation to cytokeratin 18 expression. The pancreatic cancer cell migration ability was downregulated in pancreatic cancer Aspc-1 cells that overexpressed CTRC, whereas the cell migration ability was upregulated in Aspc-1 cells in which CTRC was suppressed.
Synonym: chymase;CYH;MCT1
- 分子量
- 26.6 kDa
- UniProt
- P23946
- 途径
- ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Carbohydrate Homeostasis
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