CD3D Protein (Fc Tag)
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- 抗原 See all CD3D 蛋白
- CD3D (CD3d Molecule, delta (CD3-TCR Complex) (CD3D))
- 蛋白类型
- Recombinant
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This CD3D protein is labelled with Fc Tag.
- 原理
- Recombinant Mouse CD3d/CD3 delta Protein (Fc Tag)
- 序列
- Met1-Ala105
- 产品特性
- A DNA sequence encoding the mouse CD3D (P04235) (Met1-Ala105) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
- 纯度
- > 95 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Top Product
- Discover our top product CD3D 蛋白
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CD3d Molecule, delta (CD3-TCR Complex) (CD3D) (AA 22-105) protein (His tag)
CD3D 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
CD3d Molecule, delta (CD3-TCR Complex) (CD3D) protein (His tag)CD3D 宿主: Cynomolgus 宿主: 人细胞 Recombinant > 85 % as determined by reducing SDS-PAGE.
CD3d Molecule, delta (CD3-TCR Complex) (CD3D) protein (Fc Tag)CD3D 宿主: Cynomolgus 宿主: 人细胞 Recombinant > 90 % as determined by reducing SDS-PAGE.
CD3d Molecule, delta (CD3-TCR Complex) (CD3D) (AA 1-171) protein (GST tag)CD3D 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
CD3d Molecule, delta (CD3-TCR Complex) (CD3D) (AA 22-100) protein (GST tag)CD3D 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
CD3d Molecule, delta (CD3-TCR Complex) (CD3D) (AA 22-171) protein (rho-1D4 tag)Crystallography grade CD3D 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
CD3d Molecule, delta (CD3-TCR Complex) (CD3D) (AA 22-173) protein (rho-1D4 tag)Crystallography grade CD3D 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- CD3D (CD3d Molecule, delta (CD3-TCR Complex) (CD3D))
- 别名
- CD3d/CD3 delta (CD3D 产品)
- 别名
- CD3-DELTA Protein, T3D Protein, CD3 Protein, T3d Protein, CD3d molecule Protein, CD3 antigen, delta polypeptide Protein, CD3D Protein, Cd3d Protein
- 背景
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Background: T-cell surface glycoprotein CD3 delta chain, also known as CD3D, is a single-pass type I membrane protein. CD3D, together with CD3-gamma, CD3-epsilon and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. The majority of T cell receptor (TCR) complexes in mice and humans consist of a heterodimer of polymorphic TCRalpha and beta chains along with invariant CD3gamma, delta, epsilon, and zeta chains. CD3 chains are present as CD3gammaepsilon, deltaepsilon, and zetazeta dimers in the receptor complex and play critical roles in the antigen receptor assembly, transport to the cell surface, and the receptor-mediated signal transduction. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. The T cell receptor-CD3 complex is unique in having ten cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs). CD3D contains 1 ITAM domain and has been shown to interact with CD8A. In the mouse, knockout of CD3delta allows some degree of T lymphocyte differentiation since mature CD4 and CD8 as well as TCRgammadelta T lymphocytes are observed in the periphery. In contrast, deleterious mutation of the CD3delta encoding gene in the human leads to a severe combined immunodeficiency characterised by the complete absence of mature T cell subpopulations including TCRalpha/beta and TCRgamma/delta. Defects in CD3D cause severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T-/B+/NK+ SCID) which is a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. In humans the absence of CD3 delta results in a complete arrest in thymocyte development at the stage of double negative to double positive transition and the development of gamma delta T-cell receptor-positive T cells is also impaired.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: T3d
- 分子量
- 36.4 kDa
- UniProt
- P04235
- 途径
- TCR Signaling, CXCR4-mediated Signaling Events
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