CRADD Protein (His tag)
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- 抗原 See all CRADD 蛋白
- CRADD (CASP2 and RIPK1 Domain Containing Adaptor with Death Domain (CRADD))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This CRADD protein is labelled with His tag.
- 原理
- Recombinant Human CRADD/RAIDD Protein (His Tag)
- 序列
- Met 1-Glu 199
- 产品特性
- A DNA sequence encoding the human CRADD (P78560) (Met 1-Glu 199) was fused with a polyhistidine tag at the C-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product CRADD 蛋白
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CASP2 and RIPK1 Domain Containing Adaptor with Death Domain (CRADD) (AA 1-199) protein (GST tag)
CRADD 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
CASP2 and RIPK1 Domain Containing Adaptor with Death Domain (CRADD) (AA 1-199) protein (Strep Tag)Crystallography grade CRADD 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
CASP2 and RIPK1 Domain Containing Adaptor with Death Domain (CRADD) (AA 1-199), (full length) protein (His-SUMO Tag)CRADD 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
CASP2 and RIPK1 Domain Containing Adaptor with Death Domain (CRADD) protein (Myc-DYKDDDDK Tag)CRADD 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, 20 % glycerol, pH 8.0
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- CRADD (CASP2 and RIPK1 Domain Containing Adaptor with Death Domain (CRADD))
- 别名
- CRADD/RAIDD (CRADD 产品)
- 别名
- cradd Protein, MGC89035 Protein, zgc:101717 Protein, CRADD Protein, DKFZp468A2219 Protein, LOC100226369 Protein, raidd Protein, MGC78788 Protein, MRT34 Protein, RAIDD Protein, CASP2 and RIPK1 domain containing adaptor with death domain Protein, CASP2 and RIPK1 domain containing adaptor with death, gene 1 Protein, CASP2 and RIPK1 domain containing adaptor with death, gene 2 S homeolog Protein, CRADD Protein, cradd.1 Protein, cradd Protein, cradd.2.S Protein, Cradd Protein
- 背景
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Background: Death domain-containing protein CRADD; also known as Caspase and RIP adapter with death domain; RIP-associated protein with a death domain; CRADD and RAIDD; is a protein which is constitutively expressed in most tissues; with particularly high expression in adult heart; testis; liver; skeletal muscle; fetal liver and kidney. CRADD / RAIDD contains one CARD domain and one death domain. CRADD / RAIDD contains a death domain involved in the binding of RIP protein. The CARD domain mediates the interaction with caspase-2. FADD / MORT1 is a death domain (DD)-containing adaptor / signaling molecule that interacts with the intracellular DD of FAS / APO-I ( CD95 ) and tumor necrosis factor receptor 1 and the prodomain of caspase-8 ( Mch5 / MACH / FLICE). CRADD / RAIDD has a dual-domain structure similar to that of FADD. CRADD / RAIDD has an NH2-terminal caspase homology domain that interacts with caspase-2 and a COOH-terminal DD that interacts with RIP. CRADD / RAIDD could play a role in regulating apoptosis in mammalian cells. CRADD / RAIDD is a apoptotic adaptor molecule specific for caspase-2 and FASL / TNF receptor-interacting protein RIP. In the presence of RIP and TRADD; CRADD / RAIDD recruits caspase-2 to the TNFR-1 signalling complex.
Synonym: Death Domain-Containing Protein CRADD; Caspase and RIP Adapter with Death Domain; RIP-Associated Protein with A Death Domain; CRADD; RAIDD
- 分子量
- 24.1 kDa
- UniProt
- P78560
- 途径
- Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
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