CLEC4A Protein (His tag)
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- 抗原 See all CLEC4A 蛋白
- CLEC4A (C-Type Lectin Domain Family 4, Member A (CLEC4A))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This CLEC4A protein is labelled with His tag.
- 原理
- Recombinant Human CLEC4A/DCIR Protein (His Tag)
- 序列
- Gln 70-Leu 237
- 产品特性
- A DNA sequence encoding the human CLEC4A (NP_057268.1) extracellular domain (Gln 70-Leu 237) was expressed, with a polyhistidine tag at the N-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product CLEC4A 蛋白
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C-Type Lectin Domain Family 4, Member A (CLEC4A) (AA 70-237) protein (Fc Tag)
CLEC4A 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
C-Type Lectin Domain Family 4, Member A (CLEC4A) (AA 70-238) protein (Fc Tag)CLEC4A 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
C-Type Lectin Domain Family 4, Member A (CLEC4A) (AA 70-238) protein (His tag)CLEC4A 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
C-Type Lectin Domain Family 4, Member A (CLEC4A) (AA 1-237) protein (GST tag)CLEC4A 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
C-Type Lectin Domain Family 4, Member A (CLEC4A) (AA 1-237) protein (Strep Tag)Crystallography grade CLEC4A 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, ELISA, SDS
C-Type Lectin Domain Family 4, Member A (CLEC4A) (AA 1-238) protein (Strep Tag)Crystallography grade CLEC4A 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, ELISA, SDS
C-Type Lectin Domain Family 4, Member A (CLEC4A) (AA 70-237) protein (His tag)Crystallography grade CLEC4A 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, ELISA, SDS, Crys
C-Type Lectin Domain Family 4, Member A (CLEC4A) (AA 70-238) protein (His tag)Crystallography grade CLEC4A 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, ELISA, SDS, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- CLEC4A (C-Type Lectin Domain Family 4, Member A (CLEC4A))
- 别名
- CLEC4A/DCIR (CLEC4A 产品)
- 别名
- CLEC4A Protein, CLECSF6 Protein, DCIR Protein, DDB27 Protein, LLIR Protein, Clecsf6 Protein, Dcir1 Protein, Clec4a Protein, zinc finger protein 705A Protein, C-type lectin domain family 4 member A Protein, C-type lectin domain family 4, member A Protein, C-type lectin domain family 4, member a2 Protein, ZNF705A Protein, CLEC4A Protein, Clec4a Protein, Clec4a2 Protein
- 背景
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Background: Dendritic cell immunoreceptor (DCIR), also known as C-type lectin domain family 4 member A (CLEC4A), C-type lectin superfamily member 6 (CLECSF6), is a single-pass type II C-type lectin receptor expressed mainly in dendritic cells (DCs), which is a negative regulator of DC expansion and has a crucial role in maintaining the homeostasis of the immune system. The Dectin-2 family of C-type lectins that includes Dectin-2, BDCA-2, DCIR, DCAR, Clecsf8 and Mincle. These type II receptors contain a single extracellular carbohydrate recognition domain and have diverse functions in both immunity and homeostasis. DCIR is the only member of the family which contains a cytoplasmic signalling motif and has been shown to act as an inhibitory receptor, while BDCA-2, Dectin-2, DCAR and Mincle all associate with FcRgamma chain to induce cellular activation, including phagocytosis and cytokine production. Dectin-2 and Mincle have been shown to act as pattern recognition receptors for fungi, while DCIR acts as an attachment factor for HIV. In addition to pathogen recognition, DCIR has been shown to be pivotal in preventing autoimmune disease by controlling dendritic cell proliferation. DCIR expressed on antigen presenting cells and granulocytes and acts as an inhibitory receptor via an intracellular immunoreceptor tyrosine-based inhibitory motif (ITIM). It may also be involved via its ITIM motif in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. Additionally, DCIR can participate in the capture of HIV-1 and promote infection in trans and in cis of autologous CD4(+) T cells from human immature monocyte-derived DCs. DCIR acts as a ligand for HIV-1 and is involved in events leading to productive virus infection.
Synonym: CD367,CLEC4A,CLECSF6,DCIR,DDB27,HDCGC13P,LLIR
- 分子量
- 22 kDa
- NCBI登录号
- NP_057268
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