MERTK Protein (GST tag,His tag)
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- 抗原 See all MERTK 蛋白
- MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 小鼠
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资源
- Baculovirus infected Insect Cells
- 标记
- This MERTK protein is labelled with GST tag,His tag.
- 原理
- Recombinant Mouse MERTK/MER Protein (His & GST Tag)(Active)
- 序列
- Glu573-Tyr867
- 产品特性
- A DNA sequence encoding the mouse MERTK (Q60805) (Glu573-Tyr867) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- 纯度
- > 96 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- The specific activity was determined to be 30 nmol/min/mg using Poly(Glu,Tyr) 4:1 as substrate
- Top Product
- Discover our top product MERTK 蛋白
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C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 19-497) protein (His tag)
MERTK 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 21-505) protein (mFc Tag)MERTK 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 21-505) protein (His tag)MERTK 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 528-999) (Active) protein (GST tag)MERTK 宿主: 人 宿主: Insect cells (Sf21) Recombinant SDS, Func Active
C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 21-120) protein (GST tag)MERTK 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) protein (Fc Tag)MERTK 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE
C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) protein (GST tag,His tag)MERTK 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 92 % as determined by reducing SDS-PAGE.
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- 限制
- 仅限研究用
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- 状态
- Frozen, Liquid
- 缓冲液
- Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol
- 储存条件
- -20 °C
- 储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- 抗原
- MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))
- 别名
- MERTK/MER (MERTK 产品)
- 别名
- MER Protein, RP38 Protein, c-mer Protein, Eyk Protein, Mer Protein, Nyk Protein, nmf12 Protein, rdy Protein, C-EYK Protein, MERTK Protein, DKFZp469D2215 Protein, si:ch1073-268l12.2 Protein, MER proto-oncogene, tyrosine kinase Protein, c-mer proto-oncogene tyrosine kinase Protein, c-mer proto-oncogene tyrosine kinase a Protein, MERTK Protein, Mertk Protein, mertka Protein
- 背景
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Background: Proto-oncogene tyrosine-protein kinase MER (MERTK) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. MERTK is localized in membrane and is no expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. This protein is highly expressed in testis, ovary, prostate, lung, and kidney, with lower expression in spleen, small intestine, colon, and liver. MERTK regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. MERTK plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. Defects in MERTK are the cause of retinitis pigmentosa type 38.
Synonym: Eyk,Mer,nmf12,Nyk
- 分子量
- 61.7 kDa
- UniProt
- Q60805
- 途径
- RTK signaling
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