BLK Protein (GST tag)
-
- 抗原 See all BLK 蛋白
- BLK (B Lymphoid Tyrosine Kinase (BLK))
- 蛋白类型
- Recombinant
- 生物活性
- Active
-
宿主
- 人
-
资源
- Baculovirus infected Insect Cells
- 标记
- This BLK protein is labelled with GST tag.
- 原理
- Recombinant Human BLK Protein (GST Tag)(Active)
- 序列
- Met 1-Pro 505
- 产品特性
- A DNA sequence encoding the human BLK (NP_001706.2) (Met 1-Pro 505) was fused with the GST tag at the N-terminus.
- 纯度
- > 88 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- The specific activity was determined to be 17.4 nmol/min/mg using Poly(Glu,Tyr)4:1 peptide as substrate.
- Top Product
- Discover our top product BLK 蛋白
-
B Lymphoid Tyrosine Kinase (BLK) (AA 1-505) (Active) protein (His-GST)
BLK 宿主: 人 宿主: Insect cells (Sf9) Recombinant SDS, Func Active
B Lymphoid Tyrosine Kinase (BLK) (AA 1-505) protein (GST tag)BLK 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
B Lymphoid Tyrosine Kinase (BLK) (AA 1-90) protein (GST tag)BLK 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
B Lymphoid Tyrosine Kinase (BLK) (AA 1-505) protein (His tag)BLK 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
B Lymphoid Tyrosine Kinase (BLK) (AA 2-505) protein (His tag)Crystallography grade BLK 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
B Lymphoid Tyrosine Kinase (BLK) (AA 2-499) protein (His tag)Crystallography grade BLK 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
-
- 限制
- 仅限研究用
-
- 状态
- Frozen, Liquid
- 缓冲液
- Supplied as sterile 20 mM Tris, 500 mM NaCl, 5 mM GSH, pH 7.4
- 储存条件
- -20 °C
- 储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
-
- 抗原
- BLK (B Lymphoid Tyrosine Kinase (BLK))
- 别名
- BLK (BLK 产品)
- 别名
- bltk Protein, si:dkey-33i22.2 Protein, zgc:136231 Protein, MODY11 Protein, BLK proto-oncogene, Src family tyrosine kinase Protein, B lymphoid kinase Protein, blk Protein, BLK Protein, Blk Protein
- 背景
-
Background: Tyrosine-protein kinase Blk, also known as B lymphocyte kinase, p55-Blk and BLK, is a member of the protein kinase superfamily, Tyr protein kinase family and SRC subfamily. BLK / p55-Blk is expressed in lymphatic organs, pancreatic islets, Leydig cells, striate ducts of salivary glands and hair follicles. BLK / p55-Blk is a src-family protein tyrosine kinase specifically expressed in B-lineage cells of mice. The early onset of Blk expression during B-cell development in the bone marrow and the high expression levels of Blk in mature B cells suggest a possible important role of Blk in B-cell physiology. It is a modulator of beta-cells function, acting through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose. Defects in BLK are a cause of maturity-onset diabetes of the young type 11 which is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
Synonym: Tyrosine-Protein Kinase Blk; B Lymphocyte Kinase; p55-Blk; BLK;MODY11
- NCBI登录号
- NP_001706
- 途径
- Positive Regulation of Peptide Hormone Secretion, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling
-
