APEX1 蛋白
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北京 101111
Quick Overview for APEX1 蛋白 (ABIN7318176)
抗原
See all APEX1 蛋白蛋白类型
宿主
资源
纯度
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原理
- Recombinant Human APE1/APE Protein
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序列
- Pro2-Leu318
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产品特性
- Recombinant Human Apurinic-Apyrimidinic Endonuclease 1 is produced by our E.coli expression system and the target gene encoding Pro2-Leu318 is expressed.
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内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (AA 1-318) protein (GST tag)
APEX1 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (AA 97-195) protein (His-IF2DI Tag)APEX1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. ELISA, WB
Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (AA 1-318) protein (His tag)APEX1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. ELISA, WB
Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (AA 1-318) protein (T7 tag)APEX1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (Transcript Variant 1) proteinAPEX1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (AA 32-318) protein (His tag)APEX1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (AA 32-318) protein (His tag)APEX1 宿主: 人 宿主: 酵母菌 Recombinant > 90 % SDS
Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)APEX1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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限制
- 仅限研究用
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状态
- Frozen, Liquid
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缓冲液
- Supplied as a 0.2 μm filtered solution of 10 mM HEPES, 100 mM KCl, 50 % Glycerol, pH 7.4.
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储存条件
- -20 °C
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储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))
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别名
- APE1/APE
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背景
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Background: Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases, APE1 cleaves the AP site to allow resynthesis and ligation to complete repair. APE1 stimulates the DNA binding activity of many transcription factors, which participate in cancer promotion and progression. APE1 regulates the redox state of multiple transcription factors, such as c-Jun, c-Fos, NF-kB, p53. APEN is also involved in calcium-dependent down-regulation of PTH expression.
Synonym: DNA-(Apurinic or Apyrimidinic Site) Lyase, APEX Nuclease, APEN, Apurinic-Apyrimidinic Endonuclease 1, AP Endonuclease 1, APE-1REF-1, Redox Factor-1, APEX1, APE, APE1, APEX, APX, HAP1, REF1
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分子量
- 35.6 kDa
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UniProt
- P27695
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途径
- DNA Damage Repair, Chromatin Binding, Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Positive Regulation of Response to DNA Damage Stimulus
抗原
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