AGT Protein (His tag)
-
- 抗原 See all AGT 蛋白
- AGT (Angiotensinogen (serpin Peptidase Inhibitor, Clade A, Member 8) (AGT))
- 蛋白类型
- Recombinant
-
宿主
- 小鼠
-
资源
- HEK-293 Cells
- 标记
- This AGT protein is labelled with His tag.
- 原理
- Recombinant Mouse SerpinA8/AGT Protein (His Tag)
- 序列
- Met 1-Val 477
- 产品特性
- A DNA sequence encoding the mouse AGT (P11859) (Met 1-Val 477) was expressed, with a C-terminal polyhistidine tag.
- 纯度
- > 96 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Top Product
- Discover our top product AGT 蛋白
-
Angiotensinogen (serpin Peptidase Inhibitor, Clade A, Member 8) (AGT) (AA 1-485) protein (GST tag)
AGT 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Angiotensinogen (serpin Peptidase Inhibitor, Clade A, Member 8) (AGT) (AA 34-485) protein (GST tag)AGT 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Angiotensinogen (serpin Peptidase Inhibitor, Clade A, Member 8) (AGT) (AA 376-485) protein (GST tag)AGT 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Angiotensinogen (serpin Peptidase Inhibitor, Clade A, Member 8) (AGT) protein (His tag)AGT 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
Angiotensinogen (serpin Peptidase Inhibitor, Clade A, Member 8) (AGT) (AA 34-485) protein (His tag)Crystallography grade AGT 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Angiotensinogen (serpin Peptidase Inhibitor, Clade A, Member 8) (AGT) (AA 25-477) protein (His tag)Crystallography grade AGT 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
-
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
-
- 抗原
- AGT (Angiotensinogen (serpin Peptidase Inhibitor, Clade A, Member 8) (AGT))
- 别名
- SerpinA8/AGT (AGT 产品)
- 别名
- ANHU Protein, SERPINA8 Protein, AI265500 Protein, AngI Protein, AngII Protein, Aogen Protein, Serpina8 Protein, ANRT Protein, Ang Protein, PAT Protein, wu:fb62f06 Protein, wu:fj87b02 Protein, zgc:111892 Protein, AGT Protein, angt Protein, ANGT Protein, angiotensinogen Protein, angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Protein, AGT Protein, Agt Protein, agt Protein
- 背景
-
Background: Angiotensinogen, also known as AGT and SerpinA8, is a member of the serpin family. It is an α-2-globulin that is produced constitutively and released into the circulation mainly by the liver. Angiotensinogen is a essential component of the renin-angiotensin system (RAS) and a potent regulator of blood pressure. Angiotensinogen can be schematically considered to consist of a combination of an angiotensin I (Ang I) function, located at the N-terminal end, and the presence of a serpin (serine protease inhibitor) structure at the opposite end. Angiotensinogen is cleaved into three chains: Angiotensin-1 (Ang I), Angiotensin-2 (Ang II), and Angiotensin-3 (Ang III). Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-7 is cleaved from angiotensin-2 by ACE2. Angiotensin-2 acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system. Defects in AGT are associated with susceptibility to essential hypertension and renal tubular dysgenesis (RTD). Several serpins (antithrombin, maspin, pigment epithelial-derived factor, and kallistatin) have been recently shown to exert an antiangiogenic activity, suggesting a common mechanism of endothelial cell proliferation and migration. Angiotensinogen/AGT and its renin-cleaved product, des(Ang I)AGT, are also angiogenesis inhibitors, both in vitro and in vivo at concentrations within the range of those observed in plasma. The Angiotensinogen products, that is angiotensin II and possibly angiotensin II-related products, have been found to act locally in modulating adipose tissue growth in an autocrine/paracrine manner. The transient or chronic overexpression of angiotensinogen in adipose tissue favors lipogenesis in adipocytes and leads to a 'vicious' circle whereby adipose tissue development is further increased.
Synonym: AI265500;AngI;AngII;Aogen;Serpina8
- 分子量
- 50.8 kDa
- UniProt
- P11859
- 途径
- JAK/STAT Signaling, ACE Inhibitor Pathway, EGFR Signaling Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Regulation of Lipid Metabolism by PPARalpha, Protein targeting to Nucleus, Feeding Behaviour, Monocarboxylic Acid Catabolic Process, Dicarboxylic Acid Transport, Positive Regulation of Response to DNA Damage Stimulus, Regulation of long-term Neuronal Synaptic Plasticity
-
