ACVRL1 Protein (Fc Tag)
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- 抗原 See all ACVRL1 蛋白
- ACVRL1 (Activin A Receptor Type II-Like 1 (ACVRL1))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This ACVRL1 protein is labelled with Fc Tag.
- 原理
- Recombinant Human ALK-1/ACVRL1 Protein (Fc Tag)(Active)
- 序列
- Met 1-Gln 118
- 产品特性
- A DNA sequence encoding the N-terminal segment (Met 1-Gln 118) of the extracellular domain of human ALK1 (NP_000011.2) pro-protein was fused with the Fc region of human IgG1 at the C-terminus.
- 纯度
- > 97 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- 1.Measured by its ability to bind Human ENG-Fc in functional Elisa.2. Measured by its ability to latent TGFB1-His in functional Elisa.3. Measured by its ability to mouse ENG-His in functional Elisa.4. Measured by its ability to inhibit BMP9 induced alkaline phosphatase production by MC3T3E1 mouse chondrogenic cells. David, L. et al. (2007) Blood 109:1953. The ED50 for this effect is typically 5-15 ng/mL in the presence of 2 ng/mL of recombiant human BMP9.
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- Discover our top product ACVRL1 蛋白
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Activin A Receptor Type II-Like 1 (ACVRL1) (AA 22-118) protein (His tag)
ACVRL1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Activin A Receptor Type II-Like 1 (ACVRL1) protein (Fc Tag)ACVRL1 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE
Activin A Receptor Type II-Like 1 (ACVRL1) (AA 22-503) protein (GST tag)ACVRL1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Activin A Receptor Type II-Like 1 (ACVRL1) (AA 22-119) protein (GST tag)ACVRL1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Activin A Receptor Type II-Like 1 (ACVRL1) (Active) protein (His tag,Fc Tag)ACVRL1 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE Active
Activin A Receptor Type II-Like 1 (ACVRL1) (Active) protein (His tag,Fc Tag)ACVRL1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- ACVRL1 (Activin A Receptor Type II-Like 1 (ACVRL1))
- 别名
- ALK-1/ACVRL1 (ACVRL1 产品)
- 别名
- ACVRL1 Protein, vgb Protein, alk1 Protein, zehn1109 Protein, hm:zehn1109 Protein, ACVRLK1 Protein, ALK-1 Protein, ALK1 Protein, HHT Protein, HHT2 Protein, ORW2 Protein, SKR3 Protein, TSR-I Protein, R-3 Protein, R3 Protein, SETHKIR Protein, AI115505 Protein, AI427544 Protein, Acvrlk1 Protein, Alk1 Protein, activin A receptor like type 1 Protein, activin A receptor type II-like 1 Protein, activin A receptor, type II-like 1 Protein, ACVRL1 Protein, acvrl1 Protein, Acvrl1 Protein
- 背景
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Background: Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. On ligand binding, a heteromeric receptor complex forms consisting of two type II and two type I transmembrane serine/threonine kinases. ACVRL1 protein is expressed in certain blood vessels of kidney, spleen, heart and intestine, serving as an important role during vascular development. Mutations in ACVRL1 gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2 and vascular disease.
Synonym: Serine/Threonine-Protein Kinase Receptor R3, SKR3, Activin Receptor-Like Kinase 1, ALK-1, TGF-B Superfamily Receptor Type I, TSR-I, ACVRL1, ACVRLK1, ALK1,HHT,HHT2,ORW2,SKR3
- 分子量
- 37.4 kDa
- NCBI登录号
- NP_000011
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