PFKFB3 Protein (His tag)
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- 抗原 See all PFKFB3 蛋白
- PFKFB3 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This PFKFB3 protein is labelled with His tag.
- 原理
- Recombinant Human PFKFB3 (N-6His)
- 序列
- Met1-His520
- 产品特性
- Recombinant Human 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 is produced by our E.coli expression system and the target gene encoding Met1-His520 is expressed with a 6His tag at the N-terminus.
- 纯度
- >95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product PFKFB3 蛋白
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6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3) (AA 1-520) protein (GST tag)
PFKFB3 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3) (AA 412-520) protein (GST tag)PFKFB3 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3) protein (GST tag,His tag)PFKFB3 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 85 % as determined by reducing SDS-PAGE.
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- 限制
- 仅限研究用
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- 状态
- Frozen, Liquid
- 缓冲液
- Supplied as a 0.2 μm filtered solution of 50 mM Tris-HCl, 50 mM KCl, 1 mM DTT, 0.1 mM EDTA, 20 % Glycerol, pH 8.0.
- 储存条件
- -20 °C
- 储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- 抗原
- PFKFB3 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3))
- 别名
- PFKFB3 (PFKFB3 产品)
- 别名
- IPFK2 Protein, PFK2 Protein, E330010H22Rik Protein, iPFK-2 Protein, uPFK-2 Protein, PFKFB3 Protein, zgc:73257 Protein, wu:fc31e01 Protein, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Protein, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 S homeolog Protein, PFKFB3 Protein, Pfkfb3 Protein, pfkfb3.S Protein, pfkfb3 Protein, PTRG_09894 Protein, Tsp_06710 Protein
- 背景
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Background: Fructose-2,6-biphosphatase 3, also known as 6-phosphofructo-2-kinase or PFK2 or PFKFB3, involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls the activity of the enzymes phosphofructokinase 1 (PFK-1) and fructose 1,6-bisphosphatase (FBPase-1) to regulate glycolysis and gluconeogenesis. Highly phosphorylated PFKFB3 protein was found in human tumor cells, vascular endothelial cells, and smooth muscle cells. Because of its proto-oncogenic character, the PFK-2/FBPase-2 of the PFKFB3 gene is assumed to play a critical role in tumorigenesis. PFKFB3 also plays a crucial role in the progression of cancerous cells by enabling their glycolytic pathways even under severe hypoxic conditions, which makes it a potential target for cancer therapy.
Synonym: IPFK2, PFK2, iPFK-2, PFK/FBPase 3
- 分子量
- 61.8 kDa
- UniProt
- Q16875
- 途径
- AMPK Signaling, Regulation of Carbohydrate Metabolic Process
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