MARCO
宿主: Golden Syrian Hamster
宿主: 酵母菌
Recombinant
> 90 %
ELISA
应用备注
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 45.6 kDa. The protein migrates as 60-70 kDa under reducing (R) condition due to glycosylation.
限制
仅限研究用
状态
Lyophilized
缓冲液
PBS, pH 7.4
储存条件
-20 °C
储存方法
-20°C
抗原
MARCO
(Macrophage Receptor with Collagenous Structure (MARCO))
AI323439 Protein, Ly112 Protein, Scara2 Protein, SCARA2 Protein, macrophage receptor with collagenous structure Protein, MARCO Protein, Marco Protein
背景
Synonyms: MARCO, SCARA2, Macrophage receptor with collagenous structure, Scavenger receptor class A member 2, Description: MARCO is also known as Scavenger receptor class A member 2 and SCARA2. Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria. Also plays a role in binding of unopsonized particles by alveolar macrophages. Binds to the secretoglobin SCGB3A2. MARCO ligation promotes the production of inflammatory mediators by macrophages. MARCO mediated internalization of some ligands prevents their activation of cell surface TLR4 but enables their activation of intracellular TLR3. MARCO contributes to the clearance of apoptotic cells and inhaled bacteria, mast cell mediated silicosis, and the amelioration of allergen or ozone induced lung inflammation. It is required for the organization of the splenic marginal zone and the interaction of splenic macrophages and B cells.