IL21 Receptor Protein (mFc Tag)
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- 抗原 See all IL21 Receptor (IL21R) 蛋白
- IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This IL21 Receptor protein is labelled with mFc Tag.
- 原理
- Recombinant Human IL21R with C-terminal mouse Fc tag
- 特异性
- IL21R (Cys20-Glu232) mFc (Pro99-Lys330)
- 产品特性
- Extracellular Domain Protein
- 纯化方法
- affinity purification
- 纯度
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
- Top Product
- Discover our top product IL21R 蛋白
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Reconstitute with deionized water
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 有效期
- 12 months
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- 抗原
- IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))
- 别名
- IL21R (IL21R 产品)
- 别名
- IL21R Protein, il-21ra.a Protein, CD360 Protein, NILR Protein, interleukin 21 receptor Protein, interleukin 21 receptor, tandem duplicate 1 Protein, IL21R Protein, il21r.1 Protein, Il21r Protein
- 背景
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Synonymes: CD360, IMD56, NILR
Description: The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. - 分子量
- predicted molecular mass of 50.7 kDa after removal of the signal peptide.The apparent molecular mass of IL21R-mFc is 55-70 kDa due to glycosylation.
- UniProt
- Q9HBE5
- 途径
- JAK/STAT Signaling
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