ALK Protein (Fc Tag)
ALK
宿主: 人
宿主: HEK-293 Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
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- 抗原 See all ALK products
- ALK (Anaplastic Lymphoma Receptor tyrosine Kinase (ALK))
- 蛋白类型
- Recombinant
- 宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This ALK protein is labelled with Fc Tag.
- 原理
- Recombinant Human ALK Protein with C-terminal human Fc tag
- 特异性
- ALK (Ser31-Gln692) hFc (Glu99-Ala330)
- 产品特性
- Extracellular Domain Protein
- 纯化方法
- affinity purification
- 纯度
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
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Anaplastic Lymphoma Receptor tyrosine Kinase (ALK) (AA 1406-1545) protein (His-IF2DI Tag)
ALK 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Reconstitute with deionized water
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 有效期
- 12 months
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- 抗原
- ALK (Anaplastic Lymphoma Receptor tyrosine Kinase (ALK))
- 别名
- ALK (ALK 产品)
- 别名
- Tcrz Protein, CD246 Protein, NBLST3 Protein, ALK Protein, anaplastic lymphoma kinase Protein, anaplastic lymphoma receptor tyrosine kinase Protein, ALK receptor tyrosine kinase Protein, Alk Protein, ALK Protein
- 背景
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Synonymes: CD246, NBLST3
Description: This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011] - 分子量
- predicted molecular mass of 136.4 kDa after removal of the signal peptide.The apparent molecular mass of ALK-hFc is 130-250 kDa due to glycosylation.
- UniProt
- Q9UM73
- 途径
- RTK signaling
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