NRG1-beta 1 Protein (AA 2-246) (Fc Tag)
NRG1-beta 1
宿主: 人
宿主: HEK-293 Cells
Recombinant
>90 % as determined by SDS-PAGE.
Active
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- 抗原 See all NRG1-beta 1 products
- NRG1-beta 1 (Neuregulin-1 beta 1 (NRG1-beta 1))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 2-246
- 宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This NRG1-beta 1 protein is labelled with Fc Tag.
- 产品特性
- Human NRG1 Beta 1 Protein, Fc Tag
- 纯度
- >90 % as determined by SDS-PAGE.
- 内毒素水平
- Less than 1.0 EU per μg by the LAL method.
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- PBS, pH 7.4
- 储存条件
- -20 °C
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- 抗原
- NRG1-beta 1 (Neuregulin-1 beta 1 (NRG1-beta 1))
- 别名
- NRG1 Beta 1 (NRG1-beta 1 产品)
- 背景
- NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specific and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains, and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through their displayed interaction with ERBB receptors, NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells.
- 分子量
- 53.2 kDa
- NCBI登录号
- NP_039250
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