Leptin Protein (LEP)
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- 抗原 See all Leptin (LEP) 蛋白
- Leptin (LEP)
- 蛋白类型
- Recombinant
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宿主
- 小鼠
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资源
- 大肠杆菌(E. Coli)
- 应用范围
- SDS-PAGE (SDS)
- 产品特性
- Leptin Mouse, Recombinant, E.coli
- 纯度
- > 95 % by SDS - PAGE
- Top Product
- Discover our top product LEP 蛋白
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- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/ml (determined by Bradford assay)
- 缓冲液
- Liquid. In Phosphate buffered saline pH7.4
- 储存条件
- 4 °C
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- 抗原
- Leptin (LEP)
- 别名
- Leptin (LEP 产品)
- 别名
- ob Protein, obese Protein, LEPD Protein, OB Protein, OBS Protein, leptin Protein, Lep Protein, LEP Protein, lep Protein
- 背景
- Leptin is a 16-kDa nonglycosylated hormone that is produced in mature adipocytes. Leptin acts primarily in the hypothalamus to reduce food intake and body weight. In ob/ob mice, the gene encoding leptin is mutated, resulting in morbid obesity and associated abnormalities, including hyperphagia, hypothermia, diabetes and infertility. Originally discovered in the mouse, the cDNA for leptin has been so far cloned from a variety of species including human, rat, cow, chicken, pig, sheep and dog. Recombinant mouse leptin was overexpressed as insoluble protein aggregate in E.coli and purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer. Synonyms: LEP, OB, OBS, Leptin Mouse, Obesity factor, Obese protein, Leptin,. NCBI no.: NP_032519
- 分子量
- 16 kDa (147 aa), confirmed by MALDI-TOF.
- 途径
- JAK/STAT Signaling, AMPK Signaling, Hormone Transport, Peptide Hormone Metabolism, Hormone Activity, Negative Regulation of Hormone Secretion, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Monocarboxylic Acid Catabolic Process
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