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Leptin Protein (LEP)

LEP 宿主: 小鼠 宿主: 大肠杆菌(E. Coli) Recombinant >95 % as determined by reducing SDS-PAGE.
产品编号 ABIN7320902
发货至: 中国
  • 抗原 See all Leptin (LEP) 蛋白
    Leptin (LEP)
    蛋白类型
    Recombinant
    宿主
    • 13
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    • 3
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    • 3
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    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    小鼠
    资源
    • 32
    • 20
    • 2
    • 1
    • 1
    大肠杆菌(E. Coli)
    原理
    Recombinant Mouse Leptin
    序列
    Val22-Cys167
    产品特性
    Recombinant Mouse Leptin is produced by our E.coli expression system and the target gene encoding Val22-Cys167 is expressed.
    纯度
    >95 % as determined by reducing SDS-PAGE.
    内毒素水平
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product LEP 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Please refer to the printed manual for detailed information.
    缓冲液
    Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 300 mM NaCl, pH 7.5.
    储存条件
    4 °C,-20 °C,-80 °C
    储存方法
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原
    Leptin (LEP)
    别名
    Leptin (LEP 产品)
    别名
    ob Protein, obese Protein, LEPD Protein, OB Protein, OBS Protein, leptin Protein, Lep Protein, LEP Protein, lep Protein
    背景

    Background: Leptin is a hormone secreted from white adipocytes and plays important role in the regulation of food intake and energy balance. Leptin functions via signaling pathways involving OB-R in hypothalamus. Animal models have revealed the influence of Leptin in reducing body weight and regulating blood glucose level. When mutations are introduced in obese gene, mice with impaired function of leptin are massively obese and in high risk of diabetes. Leptin deficiency reduces metablic rate. Leptin deficient mice are less active and with lower body temperature than normal animals. Human Leptin shares approximately 84 % sequence identity with the mouse protein. Human Leptin consists of 167 amino acid residue including a 21 amino acid residue signal sequence and 146 amino acid residue mature protein sequence.

    Synonym: Leptin, Obese Protein, Obesity Factor, LEP, OB, OBS

    分子量
    16.1 kDa
    UniProt
    Q544U0
    途径
    JAK/STAT Signaling, AMPK Signaling, Hormone Transport, Peptide Hormone Metabolism, Hormone Activity, Negative Regulation of Hormone Secretion, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Monocarboxylic Acid Catabolic Process
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