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Leptin Protein (LEP)

LEP 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 95 % by SDS - PAGE SDS
产品编号 ABIN666843
发货至: 中国
  • 抗原 See all Leptin (LEP) 蛋白
    Leptin (LEP)
    蛋白类型
    Recombinant
    宿主
    • 13
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    • 4
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    • 3
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    • 3
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    • 1
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    • 1
    • 1
    资源
    • 33
    • 20
    • 2
    • 1
    • 1
    大肠杆菌(E. Coli)
    应用范围
    SDS-PAGE (SDS)
    产品特性
    Leptin Human Recombinant, expressed in E.coli
    纯度
    > 95 % by SDS - PAGE
    Top Product
    Discover our top product LEP 蛋白
  • 限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/ml (determined by Bradford assay)
    缓冲液
    Form : Liquid. In Phosphate buffered saline, pH 7.4.
    储存条件
    4 °C
  • 抗原
    Leptin (LEP)
    别名
    Leptin (LEP 产品)
    别名
    ob Protein, obese Protein, LEPD Protein, OB Protein, OBS Protein, leptin Protein, Lep Protein, LEP Protein, lep Protein
    背景
    Human leptin is a 16-kDa nonglycosylated hormone that is produced in mature adipocytes. Leptin acts primarily in the hypothalamus to reduce food intake and body weight. In ob/ob mice, the gene encoding leptin is mutated, resulting in morbid obesity and associated abnormalities, including hyperphagia, hypothermia, diabetes and infertility. The function of leptin in regulating appetite and metabolism, as well as the possibility of using leptin as a therapeutic agent, are currently under intense investigation. Recombinant human leptin was overexpressed as insoluble protein aggregate in E.coli and purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer. Synonyms: LEP, OB, OBS, Leptin, Obesity factor, Obese protein, Leptin, Leptin Murine Obesity Homolog, Leptin Precursor Obesity Factor, Obesity, Obesity homolog mouse, Obesity Murine Homolog Leptin,. NCBI no.: NP_000221
    分子量
    16 kDa (147 aa), confirmed by MALDI-TOF.
    途径
    JAK/STAT Signaling, AMPK Signaling, Hormone Transport, Peptide Hormone Metabolism, Hormone Activity, Negative Regulation of Hormone Secretion, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Monocarboxylic Acid Catabolic Process
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