Osteoprotegerin (OPG) is a member of the tumor necrosis factor (TNF)-related family, is referred to as TNFRSF11B and part of the OPG/receptor activator of NF-kB ligand (RANKL)/receptor activator of NF-kB (RANK) triad. This cytokine that lacks any apparent cell-association motifs and exists as a soluble secreted protein, network regulates the differentiation and activation of osteoclasts and hence the critical balance between bone formation (osteoblasts) and bone resorption (osteoclasts). Recombinant human osteoprotegerin protein, fused to His-tag at C-terminus, was expressed in Hi-5 cell using baculovirus expression system and purified by using conventional chromatography techniques. Synonyms: Osteoclastogenesis inhibitory factor, OPG, OCIF , Tumor necrosis factor receptor superfamily, member 11b MGC29565, TNFRSF 11B, TNFRSF11B, TR 1, TR1, Tumor Necrosis Factor Receptor Superfamily Member 11b. NCBI no.: NP_002537
分子量
45.6 kDa (398 aa) (Molecular weight on SDS-PAGE will appear higher)