Osteoprotegerin (TNFRSF11B)
(Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B))
蛋白类型
Recombinant
产品特性
AA 22-401
宿主
人
资源
HEK-293 Cells
标记
This Osteoprotegerin protein is labelled with Fc Tag.
序列
AA 22-401
产品特性
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 70.2 kDa. As a result of glycosylation, the protein migrates as 66-85 kDa under reducing (R) condition, and 130-170 kDa under non-reducing (NR) condition (SDS-PAGE).
TNFRSF11B
宿主: 人
宿主: HEK-293 Cells
Recombinant
> 95 % by SDS-PAGE.
Active
限制
仅限研究用
状态
Lyophilized
缓冲液
50 mM Tris, 100 mM Glycine, pH 7.5
注意事项
Please avoid repeated freeze-thaw cycles.
储存条件
-20 °C
储存方法
No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
抗原
Osteoprotegerin (TNFRSF11B)
(Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B))
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) is also known as Osteoclastogenesis inhibitory factor (OCIF), Osteoprotegerin (OPG). TNFRSF11B is a secreted homodimer protein, which can interact with TNFSF10 and TNFSF11. TNFRSF11B acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TNFRSF11B inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.