B7-H6 Protein (AA 25-262) (Fc Tag)
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- 抗原 See all B7-H6 (NCR3LG1) 蛋白
- B7-H6 (NCR3LG1) (Natural Killer Cell Cytotoxicity Receptor 3 Ligand 1 (NCR3LG1))
- 蛋白类型
- Recombinant
- 产品特性
- AA 25-262
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This B7-H6 protein is labelled with Fc Tag.
- 原理
- B7-H6 (human):Fc (mouse) (rec.)
- 特异性
- The extracellular domain of human B7-H6 (aa 25-262) is fused to the N-terminus of the Fc region of mouse IgG2a.
- 产品特性
- Protein. The extracellular domain of human B7-H6 (aa 25-262) is fused to the N-terminus of the Fc region of mouse IgG2a. Source: HEK 293 cells. Endotoxin content: <5EU/mg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). B7-H6 is a glycosylated member of the B7 family of immune costimulatory proteins. Orthologs in mouse and rat have not been identified. The Ig-like V domain mediates 1:1 stoichiometric binding of B7-H6 to NKp30 expressed on NK cells. It does not show binding to NKp44, NKp46, or NKG2D. Ligation of NKp30 by B7-H6 induces NK cell activation and target cell cytolysis. B7-H6 is expressed on a wide range of hematopoietic, carcinoma, and melanoma tumor cells, which is consistent with the detection of NKp30 binding sites on many tumors. The expression of NKp30 ligands on tumor cells correlates with tumor cell sensitivity to NKp30-dependent cell lysis.
- 纯度
- >98 % (SDS-PAGE)
- 内毒素水平
- <5EU/mg protein (LAL test, Lonza).
- Top Product
- Discover our top product NCR3LG1 蛋白
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Natural Killer Cell Cytotoxicity Receptor 3 Ligand 1 (NCR3LG1) (AA 25-262) protein (Fc Tag)
NCR3LG1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Natural Killer Cell Cytotoxicity Receptor 3 Ligand 1 (NCR3LG1) (AA 25-262) protein (His tag)NCR3LG1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Natural Killer Cell Cytotoxicity Receptor 3 Ligand 1 (NCR3LG1) (AA 25-259) protein (His tag)NCR3LG1 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Natural Killer Cell Cytotoxicity Receptor 3 Ligand 1 (NCR3LG1) (AA 25-262) protein (His-Avi Tag,Biotin)NCR3LG1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Natural Killer Cell Cytotoxicity Receptor 3 Ligand 1 (NCR3LG1) (AA 25-262) (Active) protein (His tag)NCR3LG1 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Natural Killer Cell Cytotoxicity Receptor 3 Ligand 1 (NCR3LG1) (AA 25-262) (Active) protein (Fc Tag,AVI tag,Biotin)NCR3LG1 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Natural Killer Cell Cytotoxicity Receptor 3 Ligand 1 (NCR3LG1) (AA 25-262) (Active) protein (His tag,AVI tag,Biotin)NCR3LG1 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by reduced SDS-PAGE. Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 浓度
- Lot specific
- 缓冲液
- Lyophilized from 0.2μm-filtered solution in PBS.
- 注意事项
- Avoid freeze/thaw cycles.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- 抗原
- B7-H6 (NCR3LG1) (Natural Killer Cell Cytotoxicity Receptor 3 Ligand 1 (NCR3LG1))
- 别名
- B7-H6 (NCR3LG1 产品)
- 别名
- B7-H6 Protein, B7H6 Protein, DKFZp686O24166 Protein, natural killer cell cytotoxicity receptor 3 ligand 1 Protein, NCR3LG1 Protein
- 背景
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Product Description: B7-H6 is a glycosylated member of the B7 family of immune costimulatory proteins. Orthologs in mouse and rat have not been identified. The Ig-like V domain mediates 1:1 stoichiometric binding of B7-H6 to NKp30 expressed on NK cells. It does not show binding to NKp44, NKp46, or NKG2D. Ligation of NKp30 by B7-H6 induces NK cell activation and target cell cytolysis. B7-H6 is expressed on a wide range of hematopoietic, carcinoma, and melanoma tumor cells, which is consistent with the detection of NKp30 binding sites on many tumors. The expression of NKp30 ligands on tumor cells correlates with tumor cell sensitivity to NKp30-dependent cell lysis.
- 分子量
- ~80kDa (SDS-PAGE)
- NCBI登录号
- NP_001189368
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