Galectin 9 Protein (AA 2-323) (Fc Tag)
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- 抗原 See all Galectin 9 (LGALS9) 蛋白
- Galectin 9 (LGALS9) (Lectin, Galactoside-Binding, Soluble, 9 (LGALS9))
- 蛋白类型
- Recombinant
- 产品特性
- AA 2-323
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This Galectin 9 protein is labelled with Fc Tag.
- 原理
- Galectin-9 (human):Fc (human) (rec.)
- 特异性
- The extracellular domain of human Galectin-9 (aa 2-323) is fused to the N-terminus of the Fc region of human IgG1.
- 产品特性
- Protein. The extracellular domain of human Galectin-9 (aa 2-323) is fused to the N-terminus of the Fc region of human IgG1. Source: HEK 293 cells. Endotoxin content: <5EU/mg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >95 % (SDS-PAGE). The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. Tim-3, a type I transmembrane protein, contains an immunoglobulin and a mucin-like domain in its extracellular portion and a tyrosine phosphorylation motif in its cytoplasmic portion. TIM-3 is preferentially expressed on Th1 and Tc1 cells, and generates an inhibitory signal resulting in apoptosis of Th1 and Tc1 cells. TIM-3 is also expressed on some dendritic cells and can mediate phagocytosis of apoptotic cells and cross-presentation of antigen. Tim-3 functions to inhibit aggressive Th1-mediated auto- and alloimmune responses. Tim-3 pathway blockade by administration of Tim-3:Fc fusion protein accelerates diabetes in nonobese diabetic mice, causes hyperproliferation of Th1 cells and Th1 cytokine release in an experimental autoimmune encephalomyelitis (EAE) model and prevents acquisition of transplantation tolerance induced by costimulation blockade.
- 纯度
- >95 % (SDS-PAGE)
- 内毒素水平
- <5EU/mg protein (LAL test, Lonza).
- Biological Activity Comment
- Measured by its binding ability in a functional ELISA.
- Top Product
- Discover our top product LGALS9 蛋白
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Lectin, Galactoside-Binding, Soluble, 9 (LGALS9) (AA 254-355) protein (GST tag)
LGALS9 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Lectin, Galactoside-Binding, Soluble, 9 (LGALS9) (AA 1-355) (Active) protein (His tag,GST tag)LGALS9 宿主: 人 宿主: 大肠杆菌（E. Coli） > 90 % AcA, CC Active
Lectin, Galactoside-Binding, Soluble, 9 (LGALS9) (AA 2-323) protein (His tag)LGALS9 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Lectin, Galactoside-Binding, Soluble, 9 (LGALS9) (AA 1-148) protein (His tag)LGALS9 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Lectin, Galactoside-Binding, Soluble, 9 (LGALS9) (AA 1-183) protein (His-IF2DI Tag)LGALS9 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % by SDS-PAGE gel analyses WB, ELISA
Lectin, Galactoside-Binding, Soluble, 9 (LGALS9) protein (GST tag)LGALS9 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % as determined by reducing SDS-PAGE.
Lectin, Galactoside-Binding, Soluble, 9 (LGALS9) protein (GST tag)LGALS9 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by reducing SDS-PAGE.
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 浓度
- Lot specific
- 缓冲液
- Lyophilized from 0.2μm-filtered solution in PBS.
- 注意事项
- Avoid freeze/thaw cycles.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- 抗原
- Galectin 9 (LGALS9) (Lectin, Galactoside-Binding, Soluble, 9 (LGALS9))
- 别名
- Galectin-9 (LGALS9 产品)
- 别名
- huat Protein, lgals9a Protein, ecalectin Protein, galectin-9 Protein, Lgals9 Protein, wu:fd20c09 Protein, zgc:111833 Protein, LGALS9 Protein, AA407335 Protein, AI194909 Protein, AI265545 Protein, LGALS35 Protein, Lgals5 Protein, gal-9 Protein, HUAT Protein, LGALS9A Protein, UAT Protein, UATP.I Protein, galectin 9 L homeolog Protein, galectin 9 Protein, lectin, galactoside-binding, soluble, 9 (galectin 9)-like 3 Protein, lectin, galactose binding, soluble 9 Protein, lgals9.L Protein, lgals9 Protein, lgals9l3 Protein, LGALS9 Protein, Lgals9 Protein
- 背景
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Alternate Names/Synonyms: Gal-9, Ecalectin, TIM3L, TIM-3 Ligand, T Cell Immunoglobulin and Mucin Domain-containing Protein 3 Ligand
Product Description: The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. Tim-3, a type I transmembrane protein, contains an immunoglobulin and a mucin-like domain in its extracellular portion and a tyrosine phosphorylation motif in its cytoplasmic portion. TIM-3 is preferentially expressed on Th1 and Tc1 cells, and generates an inhibitory signal resulting in apoptosis of Th1 and Tc1 cells. TIM-3 is also expressed on some dendritic cells and can mediate phagocytosis of apoptotic cells and cross-presentation of antigen. Tim-3 functions to inhibit aggressive Th1-mediated auto- and alloimmune responses. Tim-3 pathway blockade by administration of Tim-3:Fc fusion protein accelerates diabetes in nonobese diabetic mice, causes hyperproliferation of Th1 cells and Th1 cytokine release in an experimental autoimmune encephalomyelitis (EAE) model and prevents acquisition of transplantation tolerance induced by costimulation blockade.
- 分子量
- ~70kDa (SDS-PAGE)
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