YAP1 Protein (AA 1-504, full length) (His tag)
-
- 抗原 See all YAP1 蛋白
- YAP1 (Yes-Associated Protein 1 (YAP1))
- 蛋白类型
- Recombinant
- 产品特性
- full length, AA 1-504
-
宿主
- 人
-
资源
- 酵母菌
- 标记
- This YAP1 protein is labelled with His tag.
- 应用范围
- SDS-PAGE (SDS)
- 序列
- MDPGQQPPPQ PAPQGQGQPP SQPPQGQGPP SGPGQPAPAA TQAAPQAPPA GHQIVHVRGD SETDLEALFN AVMNPKTANV PQTVPMRLRK LPDSFFKPPE PKSHSRQAST DAGTAGALTP QHVRAHSSPA SLQLGAVSPG TLTPTGVVSG PAATPTAQHL RQSSFEIPDD VPLPAGWEMA KTSSGQRYFL NHIDQTTTWQ DPRKAMLSQM NVTAPTSPPV QQNMMNSASG PLPDGWEQAM TQDGEIYYIN HKNKTTSWLD PRLDPRFAMN QRISQSAPVK QPPPLAPQSP QGGVMGGSNS NQQQQMRLQQ LQMEKERLRL KQQELLRQAM RNINPSTANS PKCQELALRS QLPTLEQDGG TQNPVSSPGM SQELRTMTTN SSDPFLNSGT YHSRDESTDS GLSMSSYSVP RTPDDFLNSV DEMDTGDTIN QSTLPSQQNR FPDYLEAIPG TNVDLGTLEG DGMNIEGEEL MPSLQEALSS DILNDMESVL AATKLDKESF LTWL
- 纯化方法
- SDS-PAGE
- 纯度
- > 90 %
- Top Product
- Discover our top product YAP1 蛋白
-
Yes-Associated Protein 1 (YAP1) (AA 1-504) protein (GST tag)
YAP1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Yes-Associated Protein 1 (YAP1) (AA 350-504) protein (His tag)YAP1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Yes-Associated Protein 1 (YAP1) (AA 53-161) protein (GST tag)YAP1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Yes-Associated Protein 1 (YAP1) (AA 1-504) protein (Strep Tag)Crystallography grade YAP1 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Yes-Associated Protein 1 (YAP1) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)YAP1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
-
- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 0.1-2 mg/mL
- 缓冲液
- 20 mM Tris-HCl based buffer, pH 8.0
- 储存条件
- -80 °C,4 °C,-20 °C
- 储存方法
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
-
- 抗原
- YAP1 (Yes-Associated Protein 1 (YAP1))
- 别名
- YAP1 (YAP1 产品)
- 别名
- YAP Protein, YAP2 Protein, YAP65 Protein, YKI Protein, xyap Protein, yap Protein, yap2 Protein, yap65 Protein, yki Protein, AI325207 Protein, Yap Protein, Yap65 Protein, Yki Protein, Yorkie Protein, cb194 Protein, sb:cb194 Protein, si:ch211-181p1.5 Protein, si:dkey-3b8.3 Protein, wu:fc18c04 Protein, zgc:158380 Protein, Yes associated protein 1 Protein, Yes associated protein 1 S homeolog Protein, yes-associated protein 1 Protein, Yes-associated protein 1 Protein, YAP1 Protein, yap1.S Protein, Yap1 Protein, yap1 Protein
- 背景
- Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (T) induction. Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3).
- 分子量
- 56.4 kDa
- UniProt
- P46937
- 途径
- MAPK Pathway, Stem Cell Maintenance, Regulation of Lipid Metabolism by PPARalpha
-
