Optimal working dilution should be determined by the investigator.
限制
仅限研究用
状态
Liquid
浓度
0.1-2 mg/mL
缓冲液
20 mM Tris-HCl based buffer, pH 8.0
储存条件
-80 °C,4 °C,-20 °C
储存方法
Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
抗原
BRMS1
(Breast Cancer Metastasis Suppressor 1 (BRMS1))
MGC98869 Protein, BRMS1 Protein, BRMS1L Protein, AV003220 Protein, AW554636 Protein, si:zc188c22.3 Protein, si:zc194c5.2 Protein, wu:fb57b08 Protein, zgc:56414 Protein, breast cancer metastasis suppressor 1 Protein, breast cancer metastasis-suppressor 1 Protein, breast cancer metastasis suppressor 1 L homeolog Protein, BRMS1 Protein, Brms1 Protein, brms1.L Protein, brms1 Protein
背景
Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.