FZR1 Protein (AA 1-493, full length) (His-SUMO Tag)
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- 抗原 See all FZR1 蛋白
- FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))
- 蛋白类型
- Recombinant
- 产品特性
- full length, AA 1-493
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This FZR1 protein is labelled with His-SUMO Tag.
- 应用范围
- SDS-PAGE (SDS)
- 序列
- MDQDYERRLL RQIVIQNENT MPRVTEMRRT LTPASSPVSS PSKHGDRFIP SRAGANWSVN FHRINENEKS PSQNRKAKDA TSDNGKDGLA YSALLKNELL GAGIEKVQDP QTEDRRLQPS TPEKKGLFTY SLSTKRSSPD DGNDVSPYSL SPVSNKSQKL LRSPRKPTRK ISKIPFKVLD APELQDDFYL NLVDWSSLNV LSVGLGTCVY LWSACTSQVT RLCDLSVEGD SVTSVGWSER GNLVAVGTHK GFVQIWDAAA GKKLSMLEGH TARVGALAWN AEQLSSGSRD RMILQRDIRT PPLQSERRLQ GHRQEVCGLK WSTDHQLLAS GGNDNKLLVW NHSSLSPVQQ YTEHLAAVKA IAWSPHQHGL LASGGGTADR CIRFWNTLTG QPLQCIDTGS QVCNLAWSKH ANELVSTHGY SQNQILVWKY PSLTQVAKLT GHSYRVLYLA MSPDGEAIVT GAGDETLRFW NVFSKTRSTK ESVSVLNLFT RIR
- 纯化方法
- SDS-PAGE
- 纯度
- > 90 %
- Top Product
- Discover our top product FZR1 蛋白
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Fizzy/cell Division Cycle 20 Related 1 (FZR1) (AA 1-493) protein (GST tag)
FZR1 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Fizzy/cell Division Cycle 20 Related 1 (FZR1) (AA 1-101) protein (GST tag)FZR1 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Fizzy/cell Division Cycle 20 Related 1 (FZR1) (AA 1-496) protein (Strep Tag)Crystallography grade FZR1 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB
Fizzy/cell Division Cycle 20 Related 1 (FZR1) (AA 1-493) protein (Strep Tag)Crystallography grade FZR1 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB
Fizzy/cell Division Cycle 20 Related 1 (FZR1) (AA 13-314) protein (His-SUMO Tag)FZR1 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
Fizzy/cell Division Cycle 20 Related 1 (FZR1) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)FZR1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.1-2 mg/mL
- 缓冲液
- 20 mM Tris-HCl based buffer, pH 8.0
- 储存条件
- -80 °C,4 °C,-20 °C
- 储存方法
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- 抗原
- FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))
- 别名
- FZR (FZR1 产品)
- 别名
- CDH1-C Protein, FYR Protein, FZR Protein, CDH1 Protein, fzr1 Protein, CDC20C Protein, FZR2 Protein, HCDH Protein, HCDH1 Protein, AW108046 Protein, Cdh1 Protein, Fyr Protein, zgc:55450 Protein, fizzy and cell division cycle 20 related 1 Protein, fizzy/cell division cycle 20 related 1 Protein, fizzy-related protein homolog Protein, fizzy/cell division cycle 20 related 1 (Drosophila) Protein, fizzy/cell division cycle 20 related 1a Protein, Fzr1 Protein, CDH1-C Protein, FZR1 Protein, LOC100027495 Protein, LOC100179951 Protein, fzr1a Protein
- 背景
- Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacent of CDC20, and activates the APC/C during anaphase and telophase. The APC/C rains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate praturely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
- 分子量
- 70.73 kDa
- UniProt
- Q9UM11
- 途径
- DNA Replication, Synthesis of DNA
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