Chemerin Protein (AA 21-157) (His-SUMO Tag)
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- 抗原 See all Chemerin (RARRES2) 蛋白
- Chemerin (RARRES2) (Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2))
- 蛋白类型
- Recombinant
- 产品特性
- AA 21-157
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This Chemerin protein is labelled with His-SUMO Tag.
- 应用范围
- SDS-PAGE (SDS)
- 序列
- ELTEAQRRGL QVALEEFHKH PPVQWAFQET SVESAVDTPF PAGIFVRLEF KLQQTSCRKR DWKKPECKVR PNGRKRKCLA CIKLGSEDKV LGRLVHCPIE TQVLREAEEH QETQCLRVQR AGEDPHSFYF PGQFAFS
- 纯化方法
- SDS-PAGE
- 纯度
- > 90 %
- Top Product
- Discover our top product RARRES2 蛋白
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Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2) (AA 21-157) protein (His tag)
RARRES2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2) (AA 65-163) protein (GST tag)RARRES2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2) (AA 17-163) protein (GST tag)RARRES2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2) (AA 1-163) protein (GST tag)RARRES2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2) (AA 21-157) protein (His tag)Crystallography grade RARRES2 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2) (AA 21-156) protein (His tag)Crystallography grade RARRES2 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.1-2 mg/mL
- 缓冲液
- 20 mM Tris-HCl based buffer, pH 8.0
- 储存条件
- -80 °C,4 °C,-20 °C
- 储存方法
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- 抗原
- Chemerin (RARRES2) (Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2))
- 别名
- RARR2 (RARRES2 产品)
- 别名
- HP10433 Protein, TIG2 Protein, 0610007L05Rik Protein, AI303516 Protein, retinoic acid receptor responder 2 Protein, retinoic acid receptor responder (tazarotene induced) 2 Protein, RARRES2 Protein, Rarres2 Protein
- 背景
- Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chokine-like receptor 1 (CMKLR1). Its other ligands include G protein-coupled receptor 1 (GPR1) and chokine receptor-like 2 (CCRL2). Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a proinflammatory adipokine, causing an increase in secretion of proinflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells. The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production. Its dual role in inflammation and metabolism might provide a link between chronic inflammation and obesity, as well as obesity-related disorders such as type 2 diabetes and cardiovascular disease. Exhibits an antimicrobial function in the skin
- 分子量
- 31.87 kDa
- UniProt
- Q99969
- 途径
- Brown Fat Cell Differentiation
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