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- 抗原 See all NPC2 蛋白
- NPC2 (Niemann-Pick Disease, Type C2 (NPC2))
- 蛋白类型
- Recombinant
- 产品特性
- AA 22-149
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宿主
- 犬
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资源
- 大肠杆菌（E. Coli）
- 标记
- This NPC2 protein is labelled with His tag.
- 应用范围
- SDS-PAGE (SDS)
- 序列
- VHFKDCGSAV GVIKELNVNP CPAQPCKLHK GQSYSVNVTF TSNIPSQSSK AVVHGIVLGV AVPFPIPEAD GCKSGINCPI QKDKTYSYLN KLPVKNEYPS IKLVVQWMLL GDNNQHLFCW EIPVQIEG
- 纯化方法
- SDS-PAGE
- 纯度
- > 90 %
- Top Product
- Discover our top product NPC2 蛋白
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Niemann-Pick Disease, Type C2 (NPC2) (AA 1-151) protein (GST tag)
NPC2 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Niemann-Pick Disease, Type C2 (NPC2) (AA 52-151) protein (GST tag)NPC2 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Niemann-Pick Disease, Type C2 (NPC2) protein (His tag)NPC2 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
Niemann-Pick Disease, Type C2 (NPC2) (AA 20-151) protein (His tag)Crystallography grade NPC2 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB, Crys
Niemann-Pick Disease, Type C2 (NPC2) (AA 20-149) protein (His tag)Crystallography grade NPC2 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB, Crys
Niemann-Pick Disease, Type C2 (NPC2) (AA 22-149), (full length) protein (His tag)NPC2 宿主: 犬 宿主: 酵母菌 Recombinant > 90 % ELISA
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.1-2 mg/mL
- 缓冲液
- 20 mM Tris-HCl based buffer, pH 8.0
- 储存条件
- -80 °C,4 °C,-20 °C
- 储存方法
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- 抗原
- NPC2 (Niemann-Pick Disease, Type C2 (NPC2))
- 别名
- NPC2 (NPC2 产品)
- 别名
- 2700012J19Rik Protein, AA408070 Protein, AU045843 Protein, HE1 Protein, EDDM1 Protein, re1 Protein, CE1 Protein, EPI-1 Protein, cb292 Protein, sb:cb292 Protein, NPC intracellular cholesterol transporter 2 Protein, Niemann-Pick disease, type C2 Protein, Npc2 Protein, NPC2 Protein, npc2 Protein
- 背景
- Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting mbrane of late endosomes/ lysosomes to the ER and plasma mbrane by an unknown mechanism. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport .
- 分子量
- 18.1 kDa
- UniProt
- Q28895
- 途径
- SARS-CoV-2 Protein Interactome
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