NAIP Protein (AA 60-345, partial) (His-SUMO Tag)
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- 抗原 See all NAIP 蛋白
- NAIP (NLR Family, Apoptosis Inhibitory Protein (NAIP))
- 蛋白类型
- Recombinant
- 产品特性
- AA 60-345, partial
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This NAIP protein is labelled with His-SUMO Tag.
- 应用范围
- SDS-PAGE (SDS)
- 序列
- EAKRLKTFVT YEPYSSWIPQ EMAAAGFYFT GVKSGIQCFC CSLILFGAGL TRLPIEDHKR FHPDCGFLLN KDVGNIAKYD IRVKNLKSRL RGGKMRYQEE EARLASFRNW PFYVQGISPC VLSEAGFVFT GKQDTVQCFS CGGCLGNWEE GDDPWKEHAK WFPKCEFLRS KKSSEEITQY IQSYKGFVDI TGEHFVNSWV QRELPMASAY CNDSIFAYEE LRLDSFKDWP RESAVGVAAL AKAGLFYTGI KDIVQCFSCG GCLEKWQEGD DPLDDHTRCF PNCPFL
- 纯化方法
- SDS-PAGE
- 纯度
- > 90 %
- Top Product
- Discover our top product NAIP 蛋白
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NLR Family, Apoptosis Inhibitory Protein (NAIP) (AA 1294-1403) protein (GST tag)
NAIP 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
NLR Family, Apoptosis Inhibitory Protein (NAIP) (AA 1-1403) protein (Strep Tag)Crystallography grade NAIP 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
NLR Family, Apoptosis Inhibitory Protein (NAIP) (AA 1-1403) protein (Strep Tag)Crystallography grade NAIP 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
NLR Family, Apoptosis Inhibitory Protein (NAIP) proteinNAIP 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % SDS, WB, ELISA, IP
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.1-2 mg/mL
- 缓冲液
- 20 mM Tris-HCl based buffer, pH 8.0
- 储存条件
- -80 °C,4 °C,-20 °C
- 储存方法
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- 抗原
- NAIP (NLR Family, Apoptosis Inhibitory Protein (NAIP))
- 别名
- BIRC1 (NAIP 产品)
- 别名
- BIRC1 Protein, NLRB1 Protein, psiNAIP Protein, AV364616 Protein, Birc1a Protein, D13Lsd1 Protein, Naip Protein, Naip-rs1 Protein, NLR family apoptosis inhibitory protein Protein, NLR family, apoptosis inhibitory protein 1 Protein, NAIP Protein, Naip1 Protein
- 背景
- Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that ses to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy.Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assbly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria such as C.violaceum and L.pneumophila.
- 分子量
- 48.6 kDa
- UniProt
- Q13075
- 途径
- Apoptosis, Inflammasome
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