SOCS1 Protein (AA 1-211, full length) (His tag)
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- 抗原 See all SOCS1 蛋白
- SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))
- 蛋白类型
- Recombinant
- 产品特性
- full length, AA 1-211
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This SOCS1 protein is labelled with His tag.
- 应用范围
- SDS-PAGE (SDS)
- 序列
- MVAHNQVAAD NAVSTAAEPR RRPEPSSSSS SSPAAPARPR PCPAVPAPAP GDTHFRTFRS HADYRRITRA SALLDACGFY WGPLSVHGAH ERLRAEPVGT FLVRDSRQRN CFFALSVKMA SGPTSIRVHF QAGRFHLDGS RESFDCLFEL LEHYVAAPRR MLGAPLRQRR VRPLQELCRQ RIVATVGREN LARIPLNPVL RDYLSSFPFQ I
- 纯化方法
- SDS-PAGE
- 纯度
- > 90 %
- Top Product
- Discover our top product SOCS1 蛋白
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Suppressor of Cytokine Signaling 1 (SOCS1) (AA 1-212) protein (Strep Tag)
Crystallography grade SOCS1 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Suppressor of Cytokine Signaling 1 (SOCS1) (AA 1-212) protein (His tag)SOCS1 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
Suppressor of Cytokine Signaling 1 (SOCS1) (AA 1-211) protein (His tag)SOCS1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
Suppressor of Cytokine Signaling 1 (SOCS1) (AA 1-211), (full length) protein (His tag)SOCS1 宿主: 人 宿主: 酵母菌 Recombinant > 90 % SDS
Suppressor of Cytokine Signaling 1 (SOCS1) protein (Myc-DYKDDDDK Tag)SOCS1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.1-2 mg/mL
- 缓冲液
- 20 mM Tris-HCl based buffer, pH 8.0
- 储存条件
- -80 °C,4 °C,-20 °C
- 储存方法
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- 抗原
- SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))
- 别名
- SOCS1 (SOCS1 产品)
- 别名
- socs1 Protein, zgc:91868 Protein, jab Protein, cis1 Protein, ssi1 Protein, tip3 Protein, cish1 Protein, ssi-1 Protein, socs-1 Protein, SOCS1 Protein, LOC100228306 Protein, socs1b Protein, CIS1 Protein, CISH1 Protein, JAB Protein, SOCS-1 Protein, SSI-1 Protein, SSI1 Protein, TIP3 Protein, Cish1 Protein, Cish7 Protein, Socs-1 Protein, suppressor of cytokine signaling 1a Protein, suppressor of cytokine signaling 1 Protein, suppressor of cytokine signaling 1 L homeolog Protein, socs1a Protein, socs1 Protein, SOCS1 Protein, socs1.L Protein, Socs1 Protein
- 背景
- SOCS family proteins form part of a classical negative feedback syst that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival . Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Ses to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.
- 分子量
- 27.6 kDa
- UniProt
- O15524
- 途径
- JAK/STAT Signaling, Interferon-gamma Pathway, TLR signaling, Response to Growth Hormone Stimulus
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